Evidence for multiple determinants of the body mass index: The national heart, lung, and blood institute family heart study

Ingrid B. Borecki, Millicent Higgins, Pamela J. Schreiner, Donna K. Arnett, Elizabeth Mayer-Davis, Steven Hunt, Michael A. Province

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The body mass index (BMI) is a complex phenotype representing the amount of fat mass, lean mass, body build and proportions, and it is likely to be affected by various metabolic processes, hormonal effects, energy intake and expenditure, and interactions within and among these broad categories of etiologic factors. Nonetheless, several previous studies have reported evidence for major gene segregation for the BMI in various populations. Data on a random sample of Caucasian families participating in the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study were analyzed to document the extent of familial resemblance and to investigate whether a similar monogenic inheritance pattern could be detected. Genetic analysis was carried out on age- and sex-adjusted BMI values. Familial correlations were significant implying a maximal heritability, including all genetic and environmentally inherited additive factors, of 41% to 59%. Segregation analysis revealed the presence of two maximum likelihood solutions, one characterized as a recessive Mendelian gene and the other as a major effect with an ambiguous transmission pattern. The presence of two such solutions is consistent with detection of two separate factors, each influencing the BMI distribution in a substantive manner. The evidence also supports a multifactorial background for BMI and suggests that the frequencies of these two factors, one of which appears to be a gene, may vary among diverse populations in the United States.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalObesity Research
Volume6
Issue number2
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

National Heart, Lung, and Blood Institute (U.S.)
body mass index
Body Mass Index
lungs
heart
blood
monogenic inheritance
gene segregation
Recessive Genes
Somatotypes
Inheritance Patterns
lean body mass
major genes
Energy Intake
energy expenditure
Energy Metabolism
Population
Genes
genetic techniques and protocols
energy intake

Keywords

  • Major gene
  • Obesity
  • Phenocopies
  • Population heterogeneity
  • Segregation analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Borecki, I. B., Higgins, M., Schreiner, P. J., Arnett, D. K., Mayer-Davis, E., Hunt, S., & Province, M. A. (1998). Evidence for multiple determinants of the body mass index: The national heart, lung, and blood institute family heart study. Obesity Research, 6(2), 107-114.

Evidence for multiple determinants of the body mass index : The national heart, lung, and blood institute family heart study. / Borecki, Ingrid B.; Higgins, Millicent; Schreiner, Pamela J.; Arnett, Donna K.; Mayer-Davis, Elizabeth; Hunt, Steven; Province, Michael A.

In: Obesity Research, Vol. 6, No. 2, 1998, p. 107-114.

Research output: Contribution to journalArticle

Borecki, IB, Higgins, M, Schreiner, PJ, Arnett, DK, Mayer-Davis, E, Hunt, S & Province, MA 1998, 'Evidence for multiple determinants of the body mass index: The national heart, lung, and blood institute family heart study', Obesity Research, vol. 6, no. 2, pp. 107-114.
Borecki, Ingrid B. ; Higgins, Millicent ; Schreiner, Pamela J. ; Arnett, Donna K. ; Mayer-Davis, Elizabeth ; Hunt, Steven ; Province, Michael A. / Evidence for multiple determinants of the body mass index : The national heart, lung, and blood institute family heart study. In: Obesity Research. 1998 ; Vol. 6, No. 2. pp. 107-114.
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