Evidence for lateral gene transfer between archaea and bacteria from genome sequence of Thermotoga maritima

Karen E. Nelson, Rebecca A. Clayton, Steven R. Gill, Michelle L. Gwinn, Robert J. Dodson, Daniel H. Haft, Erin K. Hickey, Jeremy D. Peterson, William C. Nelson, Karen A. Ketchum, Lisa McDonald, Teresa R. Utterback, Joel Malek, Katja D. Linher, Mina M. Garrett, Ashley M. Stewart, Matthew D. Cotton, Matthew S. Pratt, Cheryl A. Phillips, Delwood RichardsonJohn Heidelberg, Granger G. Sutton, Robert D. Fleischmann, Jonathan A. Eisen, Owen White, Steven L. Salzberg, Hamilton O. Smith, J. Craig Venter, Claire M. Fraser

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The 1,860,725-base-pair genome of Thermotoga maritima MSB8 contains 1,877 predicted coding regions, 1,014 (54%) of which have functional assignments and 863 (46%) of which are of unknown function. Genome analysis reveals numerous pathways Involved in degradation of sugars and plant polysaccharides, and 108 genes that have orthologues only in the genomes of other thermophilic Eubacteria and Archaea. Of the Eubacteria sequenced to date, T. maritima has the highest percentage (24%) of genes that are most similar to archaeal genes. Eighty-one archaeal-like genes are clustered in 15 regions of the T. maritima genome that range In size from 4 to 20 kilobases. Conservation of gene order between T. maritima and Archaea In many of the clustered regions suggests that lateral gene transfer may have occurred between thermophilic Eubacteria and Archaea.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
Issue number6734
Publication statusPublished - 27 May 1999
Externally publishedYes


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Cite this

Nelson, K. E., Clayton, R. A., Gill, S. R., Gwinn, M. L., Dodson, R. J., Haft, D. H., Hickey, E. K., Peterson, J. D., Nelson, W. C., Ketchum, K. A., McDonald, L., Utterback, T. R., Malek, J., Linher, K. D., Garrett, M. M., Stewart, A. M., Cotton, M. D., Pratt, M. S., Phillips, C. A., ... Fraser, C. M. (1999). Evidence for lateral gene transfer between archaea and bacteria from genome sequence of Thermotoga maritima. Nature, 399(6734), 323-329. https://doi.org/10.1038/20601