Evidence for a Gene on Chromosome 13 Influencing Postural Systolic Blood Pressure Change and Body Mass Index

Kari E. North, Kathryn M. Rose, Ingrid B. Borecki, Albert Oberman, Steven Hunt, Michael B. Miller, John Blangero, Laura Almasy, James S. Pankow

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Previous analysis in the Hypertension Genetic Epidemiology Network (HyperGEN) of the National Heart Lung and Blood Institute (NHLBI) Family Blood Pressure Program, a multicenter study of genetic and environmental factors related to hypertension, indicated regions of linkage for blood pressure traits together with several coincident regions for phenotypically correlated traits, including systolic blood pressure (SBP) response to a postural challenge and body mass index (BMI). Motivated by these findings and by our desire to better understand the physiology of these traits, we conducted bivariate linkage analysis of postural SBP change and BMI. Sibships in HyperGEN were recruited from 5 field centers in Massachusetts, North Carolina, Minnesota, Utah, and Alabama. All available affected siblings, their parents, and selected nonmedicated offspring were recruited. Among 1636 whites and 1747 blacks, we performed a maximum likelihood bivariate genome scan for quantitative trait loci influencing postural SBP change and BMI, similarly adjusted for race, study center, sex, age, and age-by-sex interactions. Genome scans were performed using SOLAR (version 2.0) and race-specific marker allele frequencies derived from founders. The maximum genome-wide logarithm of odds (LOD) score of 3.2 was detected on chromosome 13 at 24 cM. This marker (D13S493) lies within 20 cM of a marker previously linked to BMI in the Family Heart Study and is substantially higher than the univariate linkage for each trait (LOD scores for BMI and postural SBP change were 2.4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI.

Original languageEnglish
Pages (from-to)780-784
Number of pages5
JournalHypertension
Volume43
Issue number4
DOIs
Publication statusPublished - Apr 2004
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 13
Body Mass Index
Blood Pressure
Genes
Molecular Epidemiology
Genome
Hypertension
National Heart, Lung, and Blood Institute (U.S.)
Quantitative Trait Loci
Gene Frequency
Multicenter Studies
Siblings

Keywords

  • Blood pressure
  • Body mass index
  • Genetics
  • Hypotension
  • Posture

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Evidence for a Gene on Chromosome 13 Influencing Postural Systolic Blood Pressure Change and Body Mass Index. / North, Kari E.; Rose, Kathryn M.; Borecki, Ingrid B.; Oberman, Albert; Hunt, Steven; Miller, Michael B.; Blangero, John; Almasy, Laura; Pankow, James S.

In: Hypertension, Vol. 43, No. 4, 04.2004, p. 780-784.

Research output: Contribution to journalArticle

North, KE, Rose, KM, Borecki, IB, Oberman, A, Hunt, S, Miller, MB, Blangero, J, Almasy, L & Pankow, JS 2004, 'Evidence for a Gene on Chromosome 13 Influencing Postural Systolic Blood Pressure Change and Body Mass Index', Hypertension, vol. 43, no. 4, pp. 780-784. https://doi.org/10.1161/01.HYP.0000118921.66329.da
North, Kari E. ; Rose, Kathryn M. ; Borecki, Ingrid B. ; Oberman, Albert ; Hunt, Steven ; Miller, Michael B. ; Blangero, John ; Almasy, Laura ; Pankow, James S. / Evidence for a Gene on Chromosome 13 Influencing Postural Systolic Blood Pressure Change and Body Mass Index. In: Hypertension. 2004 ; Vol. 43, No. 4. pp. 780-784.
@article{9b419a45d1f845e8945d539067274cda,
title = "Evidence for a Gene on Chromosome 13 Influencing Postural Systolic Blood Pressure Change and Body Mass Index",
abstract = "Previous analysis in the Hypertension Genetic Epidemiology Network (HyperGEN) of the National Heart Lung and Blood Institute (NHLBI) Family Blood Pressure Program, a multicenter study of genetic and environmental factors related to hypertension, indicated regions of linkage for blood pressure traits together with several coincident regions for phenotypically correlated traits, including systolic blood pressure (SBP) response to a postural challenge and body mass index (BMI). Motivated by these findings and by our desire to better understand the physiology of these traits, we conducted bivariate linkage analysis of postural SBP change and BMI. Sibships in HyperGEN were recruited from 5 field centers in Massachusetts, North Carolina, Minnesota, Utah, and Alabama. All available affected siblings, their parents, and selected nonmedicated offspring were recruited. Among 1636 whites and 1747 blacks, we performed a maximum likelihood bivariate genome scan for quantitative trait loci influencing postural SBP change and BMI, similarly adjusted for race, study center, sex, age, and age-by-sex interactions. Genome scans were performed using SOLAR (version 2.0) and race-specific marker allele frequencies derived from founders. The maximum genome-wide logarithm of odds (LOD) score of 3.2 was detected on chromosome 13 at 24 cM. This marker (D13S493) lies within 20 cM of a marker previously linked to BMI in the Family Heart Study and is substantially higher than the univariate linkage for each trait (LOD scores for BMI and postural SBP change were 2.4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI.",
keywords = "Blood pressure, Body mass index, Genetics, Hypotension, Posture",
author = "North, {Kari E.} and Rose, {Kathryn M.} and Borecki, {Ingrid B.} and Albert Oberman and Steven Hunt and Miller, {Michael B.} and John Blangero and Laura Almasy and Pankow, {James S.}",
year = "2004",
month = "4",
doi = "10.1161/01.HYP.0000118921.66329.da",
language = "English",
volume = "43",
pages = "780--784",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Evidence for a Gene on Chromosome 13 Influencing Postural Systolic Blood Pressure Change and Body Mass Index

AU - North, Kari E.

AU - Rose, Kathryn M.

AU - Borecki, Ingrid B.

AU - Oberman, Albert

AU - Hunt, Steven

AU - Miller, Michael B.

AU - Blangero, John

AU - Almasy, Laura

AU - Pankow, James S.

PY - 2004/4

Y1 - 2004/4

N2 - Previous analysis in the Hypertension Genetic Epidemiology Network (HyperGEN) of the National Heart Lung and Blood Institute (NHLBI) Family Blood Pressure Program, a multicenter study of genetic and environmental factors related to hypertension, indicated regions of linkage for blood pressure traits together with several coincident regions for phenotypically correlated traits, including systolic blood pressure (SBP) response to a postural challenge and body mass index (BMI). Motivated by these findings and by our desire to better understand the physiology of these traits, we conducted bivariate linkage analysis of postural SBP change and BMI. Sibships in HyperGEN were recruited from 5 field centers in Massachusetts, North Carolina, Minnesota, Utah, and Alabama. All available affected siblings, their parents, and selected nonmedicated offspring were recruited. Among 1636 whites and 1747 blacks, we performed a maximum likelihood bivariate genome scan for quantitative trait loci influencing postural SBP change and BMI, similarly adjusted for race, study center, sex, age, and age-by-sex interactions. Genome scans were performed using SOLAR (version 2.0) and race-specific marker allele frequencies derived from founders. The maximum genome-wide logarithm of odds (LOD) score of 3.2 was detected on chromosome 13 at 24 cM. This marker (D13S493) lies within 20 cM of a marker previously linked to BMI in the Family Heart Study and is substantially higher than the univariate linkage for each trait (LOD scores for BMI and postural SBP change were 2.4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI.

AB - Previous analysis in the Hypertension Genetic Epidemiology Network (HyperGEN) of the National Heart Lung and Blood Institute (NHLBI) Family Blood Pressure Program, a multicenter study of genetic and environmental factors related to hypertension, indicated regions of linkage for blood pressure traits together with several coincident regions for phenotypically correlated traits, including systolic blood pressure (SBP) response to a postural challenge and body mass index (BMI). Motivated by these findings and by our desire to better understand the physiology of these traits, we conducted bivariate linkage analysis of postural SBP change and BMI. Sibships in HyperGEN were recruited from 5 field centers in Massachusetts, North Carolina, Minnesota, Utah, and Alabama. All available affected siblings, their parents, and selected nonmedicated offspring were recruited. Among 1636 whites and 1747 blacks, we performed a maximum likelihood bivariate genome scan for quantitative trait loci influencing postural SBP change and BMI, similarly adjusted for race, study center, sex, age, and age-by-sex interactions. Genome scans were performed using SOLAR (version 2.0) and race-specific marker allele frequencies derived from founders. The maximum genome-wide logarithm of odds (LOD) score of 3.2 was detected on chromosome 13 at 24 cM. This marker (D13S493) lies within 20 cM of a marker previously linked to BMI in the Family Heart Study and is substantially higher than the univariate linkage for each trait (LOD scores for BMI and postural SBP change were 2.4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI.

KW - Blood pressure

KW - Body mass index

KW - Genetics

KW - Hypotension

KW - Posture

UR - http://www.scopus.com/inward/record.url?scp=1642542436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642542436&partnerID=8YFLogxK

U2 - 10.1161/01.HYP.0000118921.66329.da

DO - 10.1161/01.HYP.0000118921.66329.da

M3 - Article

C2 - 14967843

AN - SCOPUS:1642542436

VL - 43

SP - 780

EP - 784

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 4

ER -