Evidence by molecular profiling for a placental origin of infantile hemangioma

Carmen M. Barnés, Sui Huang, Arja Kaipainen, Despina Sanoudou, Emy J. Chen, Gabriel S. Eichler, Yuchun Guo, Ying Yu, Donald E. Ingber, John B. Mulliken, Alan H. Beggs, Judah Folkman, Steven J. Fishman

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown. We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-57O]. The transcriptomes of placenta, hemangioma, and eight normal and diseased tissues were compared by hierarchical and nonhierarchical clustering analysis of >7,800 genes. We found that the level of transcriptome similarity between placenta and hemangioma exceeded that of any other tissue compared and paralleled that observed between a given tissue and its derived tumor, such as normal and cancerous lung. The degree of similarity was even greater when a subset of endothelial cell-specific genes was analyzed. Genes preferentially expressed in both placenta and hemangiomas were identified, including 17-β hydroxysteroid dehydrogenase type 2 and tissue factor pathway inhibitor 2. These data demonstrate the value of global molecular profiling of tissues as a tool for hypothesis-driven research. Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium.

Original languageEnglish
Pages (from-to)19097-19102
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number52
DOIs
Publication statusPublished - 27 Dec 2005
Externally publishedYes

Fingerprint

Hemangioma
Placenta
Transcriptome
Endothelial Cells
Genes
Endothelium
Cluster Analysis
Neoplasms
Lung
Growth
Research

Keywords

  • Angiogenesis
  • Endothelium
  • Gene array
  • Microarray

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Barnés, C. M., Huang, S., Kaipainen, A., Sanoudou, D., Chen, E. J., Eichler, G. S., ... Fishman, S. J. (2005). Evidence by molecular profiling for a placental origin of infantile hemangioma. Proceedings of the National Academy of Sciences of the United States of America, 102(52), 19097-19102. https://doi.org/10.1073/pnas.0509579102

Evidence by molecular profiling for a placental origin of infantile hemangioma. / Barnés, Carmen M.; Huang, Sui; Kaipainen, Arja; Sanoudou, Despina; Chen, Emy J.; Eichler, Gabriel S.; Guo, Yuchun; Yu, Ying; Ingber, Donald E.; Mulliken, John B.; Beggs, Alan H.; Folkman, Judah; Fishman, Steven J.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 52, 27.12.2005, p. 19097-19102.

Research output: Contribution to journalArticle

Barnés, CM, Huang, S, Kaipainen, A, Sanoudou, D, Chen, EJ, Eichler, GS, Guo, Y, Yu, Y, Ingber, DE, Mulliken, JB, Beggs, AH, Folkman, J & Fishman, SJ 2005, 'Evidence by molecular profiling for a placental origin of infantile hemangioma', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 52, pp. 19097-19102. https://doi.org/10.1073/pnas.0509579102
Barnés, Carmen M. ; Huang, Sui ; Kaipainen, Arja ; Sanoudou, Despina ; Chen, Emy J. ; Eichler, Gabriel S. ; Guo, Yuchun ; Yu, Ying ; Ingber, Donald E. ; Mulliken, John B. ; Beggs, Alan H. ; Folkman, Judah ; Fishman, Steven J. / Evidence by molecular profiling for a placental origin of infantile hemangioma. In: Proceedings of the National Academy of Sciences of the United States of America. 2005 ; Vol. 102, No. 52. pp. 19097-19102.
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