Evaluation of the sentinel lymph node algorithm with blue dye labeling for early-stage endometrial cancer in a multicentric setting

Fabien Vidal, Pierre Leguevaque, Stephanie Motton, Jerome Delotte, Gwenael Ferron, Denis Querleu, Arash Rafii Tabrizi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives: Sentinel lymph node (SLN) removal may be a midterm between no and full pelvic dissection in early endometrial cancer. Whereas the use of blue dye alone in SLN detection has a poor accuracy, its integration in an SLN algorithm may yield better results and overcome hurdles such as the requirement of nuclear medicine facility. Methods: Sixty-six patients with clinical stage I endometrial cancer were prospectively enrolled in a multicentre study between May 2003 and June 2009. Patent blue was injected intraoperatively into the cervix. We retrospectively assessed the accuracy of a previously described SLN algorithm consisting of the following sequence: (1) pelvic node area is inspected for removal of all mapped SLN and (2) excision of every suspicious non-SLN, (3) in the absence of mapping in a hemipelvis, a standard ipsilateral lymphadenectomy is then performed. Results: Sentinel nodes were identified in 41 patients (62.1%), mostly in interiliac and obturator areas. None was detected in the para-aortic area. Detection was bilateral in 23 cases (56.1%). Seven patients (10.6%) had positive nodes. The false-negative rate was 40% using SLN detection alone. When the algorithm was applied, the false-negative ratewas 14.3%. The use of a SLN algorithm would have avoided 53% of lymphadenectomies Conclusion: Our multicentric evaluation validates the use of a SLN algorithm based on blue-only sentinel node mapping in early-stage endometrial cancer. The application of such SLN algorithm should be evaluated in a prospective context and might lead to decrease unnecessary lymphadenectomies.

Original languageEnglish
Pages (from-to)1237-1243
Number of pages7
JournalInternational Journal of Gynecological Cancer
Volume23
Issue number7
DOIs
Publication statusPublished - Sep 2013

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Endometrial Neoplasms
Coloring Agents
Lymph Node Excision
Sentinel Lymph Node
Nuclear Medicine
Cervix Uteri
Multicenter Studies
Dissection
Lymph Nodes

Keywords

  • Endometrial cancer
  • Lymphadenectomy
  • Sentinel node
  • SLN algorithm

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Evaluation of the sentinel lymph node algorithm with blue dye labeling for early-stage endometrial cancer in a multicentric setting. / Vidal, Fabien; Leguevaque, Pierre; Motton, Stephanie; Delotte, Jerome; Ferron, Gwenael; Querleu, Denis; Tabrizi, Arash Rafii.

In: International Journal of Gynecological Cancer, Vol. 23, No. 7, 09.2013, p. 1237-1243.

Research output: Contribution to journalArticle

Vidal, Fabien ; Leguevaque, Pierre ; Motton, Stephanie ; Delotte, Jerome ; Ferron, Gwenael ; Querleu, Denis ; Tabrizi, Arash Rafii. / Evaluation of the sentinel lymph node algorithm with blue dye labeling for early-stage endometrial cancer in a multicentric setting. In: International Journal of Gynecological Cancer. 2013 ; Vol. 23, No. 7. pp. 1237-1243.
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