Evaluation of the antioxidative and hypo-cholesterolemic effects of lingzhi or reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes), in ameliorating cardiovascular disease

Azizur Rahaman, Noorlidah Abdullah, Norhaniza Aminudin

Research output: Contribution to journalArticle

Abstract

Oxidative stress (OS) and hypercholesterolemia have been linked with a heightened risk of cardiovascular disease (CVD). Because of the numerous drawbacks of synthetic antioxidants and cholesterol-lowering drugs, natural antioxidative and hypocholesterolemic agents are of immense importance. This study was designed to determine both the OS-attenuating and cholesterol-lowering capacities of the hot water extract (HWE) and of five solvent-solvent- partitioned fractions of Ganoderma lucidum. In vitro antioxidative performance of G. lucidum HWE and fractions was measured through DPPH free radical scavenging, Folin-Ciocalteu assay, lipid peroxidation inhibition, and human low-density lipoprotein (LDL) oxidation inhibition. In vivo antioxidative performance of G. lucidum was assessed by measuring the plasma and liver antioxidative enzymatic activities (catalase, glutathione peroxidase, and superoxide dismutase) in G. lucidum HWE-fed rats. In the CVD tests, the HWE at 200 mg/kg b.w. lowered plasma levels of total cholesterol, triacylglycerol, and LDL cholesterol and increased high-density lipoprotein cholesterol. The current findings indicate the therapeutic potentiality of G. lucidum as an OS-attenuating and hypocholesterolemic agent en route to withstanding CVD complications.

Original languageEnglish
Pages (from-to)961-969
Number of pages9
JournalInternational Journal of Medicinal Mushrooms
Volume20
Issue number10
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Reishi
Agaricales
Cardiovascular Diseases
Oxidative Stress
Water
Cholesterol
Glutathione Peroxidase
Hypercholesterolemia
LDL Lipoproteins
Catalase
LDL Cholesterol
HDL Cholesterol
Lipid Peroxidation
Superoxide Dismutase
Free Radicals
Triglycerides
Antioxidants
Liver
Pharmaceutical Preparations

Keywords

  • Body weight
  • Ganoderma lucidum
  • Lipid peroxidation
  • Low-density lipoprotein
  • Medicinal mushrooms
  • Oxidative stress
  • Toxicity

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Pharmacology
  • Drug Discovery

Cite this

@article{b8f6b9aaa6ce4de8bf068ba08d859afc,
title = "Evaluation of the antioxidative and hypo-cholesterolemic effects of lingzhi or reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes), in ameliorating cardiovascular disease",
abstract = "Oxidative stress (OS) and hypercholesterolemia have been linked with a heightened risk of cardiovascular disease (CVD). Because of the numerous drawbacks of synthetic antioxidants and cholesterol-lowering drugs, natural antioxidative and hypocholesterolemic agents are of immense importance. This study was designed to determine both the OS-attenuating and cholesterol-lowering capacities of the hot water extract (HWE) and of five solvent-solvent- partitioned fractions of Ganoderma lucidum. In vitro antioxidative performance of G. lucidum HWE and fractions was measured through DPPH free radical scavenging, Folin-Ciocalteu assay, lipid peroxidation inhibition, and human low-density lipoprotein (LDL) oxidation inhibition. In vivo antioxidative performance of G. lucidum was assessed by measuring the plasma and liver antioxidative enzymatic activities (catalase, glutathione peroxidase, and superoxide dismutase) in G. lucidum HWE-fed rats. In the CVD tests, the HWE at 200 mg/kg b.w. lowered plasma levels of total cholesterol, triacylglycerol, and LDL cholesterol and increased high-density lipoprotein cholesterol. The current findings indicate the therapeutic potentiality of G. lucidum as an OS-attenuating and hypocholesterolemic agent en route to withstanding CVD complications.",
keywords = "Body weight, Ganoderma lucidum, Lipid peroxidation, Low-density lipoprotein, Medicinal mushrooms, Oxidative stress, Toxicity",
author = "Azizur Rahaman and Noorlidah Abdullah and Norhaniza Aminudin",
year = "2018",
month = "1",
day = "1",
doi = "10.1615/IntJMedMushrooms.2018028370",
language = "English",
volume = "20",
pages = "961--969",
journal = "International Journal of Medicinal Mushrooms",
issn = "1521-9437",
publisher = "Begell House Inc.",
number = "10",

}

TY - JOUR

T1 - Evaluation of the antioxidative and hypo-cholesterolemic effects of lingzhi or reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes), in ameliorating cardiovascular disease

AU - Rahaman, Azizur

AU - Abdullah, Noorlidah

AU - Aminudin, Norhaniza

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Oxidative stress (OS) and hypercholesterolemia have been linked with a heightened risk of cardiovascular disease (CVD). Because of the numerous drawbacks of synthetic antioxidants and cholesterol-lowering drugs, natural antioxidative and hypocholesterolemic agents are of immense importance. This study was designed to determine both the OS-attenuating and cholesterol-lowering capacities of the hot water extract (HWE) and of five solvent-solvent- partitioned fractions of Ganoderma lucidum. In vitro antioxidative performance of G. lucidum HWE and fractions was measured through DPPH free radical scavenging, Folin-Ciocalteu assay, lipid peroxidation inhibition, and human low-density lipoprotein (LDL) oxidation inhibition. In vivo antioxidative performance of G. lucidum was assessed by measuring the plasma and liver antioxidative enzymatic activities (catalase, glutathione peroxidase, and superoxide dismutase) in G. lucidum HWE-fed rats. In the CVD tests, the HWE at 200 mg/kg b.w. lowered plasma levels of total cholesterol, triacylglycerol, and LDL cholesterol and increased high-density lipoprotein cholesterol. The current findings indicate the therapeutic potentiality of G. lucidum as an OS-attenuating and hypocholesterolemic agent en route to withstanding CVD complications.

AB - Oxidative stress (OS) and hypercholesterolemia have been linked with a heightened risk of cardiovascular disease (CVD). Because of the numerous drawbacks of synthetic antioxidants and cholesterol-lowering drugs, natural antioxidative and hypocholesterolemic agents are of immense importance. This study was designed to determine both the OS-attenuating and cholesterol-lowering capacities of the hot water extract (HWE) and of five solvent-solvent- partitioned fractions of Ganoderma lucidum. In vitro antioxidative performance of G. lucidum HWE and fractions was measured through DPPH free radical scavenging, Folin-Ciocalteu assay, lipid peroxidation inhibition, and human low-density lipoprotein (LDL) oxidation inhibition. In vivo antioxidative performance of G. lucidum was assessed by measuring the plasma and liver antioxidative enzymatic activities (catalase, glutathione peroxidase, and superoxide dismutase) in G. lucidum HWE-fed rats. In the CVD tests, the HWE at 200 mg/kg b.w. lowered plasma levels of total cholesterol, triacylglycerol, and LDL cholesterol and increased high-density lipoprotein cholesterol. The current findings indicate the therapeutic potentiality of G. lucidum as an OS-attenuating and hypocholesterolemic agent en route to withstanding CVD complications.

KW - Body weight

KW - Ganoderma lucidum

KW - Lipid peroxidation

KW - Low-density lipoprotein

KW - Medicinal mushrooms

KW - Oxidative stress

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=85060384713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060384713&partnerID=8YFLogxK

U2 - 10.1615/IntJMedMushrooms.2018028370

DO - 10.1615/IntJMedMushrooms.2018028370

M3 - Article

AN - SCOPUS:85060384713

VL - 20

SP - 961

EP - 969

JO - International Journal of Medicinal Mushrooms

JF - International Journal of Medicinal Mushrooms

SN - 1521-9437

IS - 10

ER -