Evaluation of human major histocompatibility complex class I chain-related A as a potential target for tumor imaging

Bixia Tang, Zhi Yang, Jie Huang, Zhiyong Hao, Wenjing Li, Lianxian Cui, Wei He

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To investigate the feasibility of using human major histocompatibility complex class I chain-related A (MICA) as a target for tumor imaging diagnosis, 10C6, a monoclonal antibody (mAb) that specifically recognizes MICA in vitro, was labeled with 99mTc (technetium) and administered into mice bearing MICA-positive human ovarian epithelial carcinoma line SKOV3. Measurement of organ-specific radioactivity showed that tumor accumulated radioactivity continuously, while the uptake in the other organs decreased over time. Scintigram showed that the tumor became clearly visible at 24 h post-injection of radio-labeled 10C6 mAb. These results suggest that MICA is a promising target for tumor imaging and mAb 10C6 may be used clinically for early tumor diagnosis.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalCancer Letters
Volume263
Issue number1
DOIs
Publication statusPublished - 8 May 2008
Externally publishedYes

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Keywords

  • Antibody
  • Diagnosis
  • Imaging
  • MICA
  • Ovarian epithelial carcinoma
  • Technetium

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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