Eukaryotic translation initiation factor 5A (EIF5A) regulates pancreatic cancer metastasis by modulating RhoA and rho-associated kinase (ROCK) protein expression levels

Ken Fujimura, Sunkyu Choi, Meghan Wyse, Jan Strnadel, Tracy Wright, Richard Klemke

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Eukaryotic translation initiation factor 5A (eIF5A) regulates pancreatic cancer pathogenesis. Results: eIF5A was shown to control the expression of a set of key signaling molecules including RhoA and ROCK2, and to promote the invasive potential of pancreatic cancer cells. Conclusion: Hypusine/eIF5A/RhoA/ROCK cascade promotes pancreatic cancer cell metastasis. Significance: eIF5A may be a novel druggable target to treat metastatic pancreatic cancer.

Original languageEnglish
Pages (from-to)29907-29919
Number of pages13
JournalJournal of Biological Chemistry
Volume290
Issue number50
DOIs
Publication statusPublished - 11 Dec 2015
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this