Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence

Marjonneke J. Mook-Kanamori, Mohammed M. El-Din Selim, Ahmed H. Takiddin, Hala Al-Homsi, Khoulood A S Al-Mahmoud, Amina Al-Obaidli, Mahmoud A. Zirie, Jillian Rowe, Wafaa Sekkal Gherbi, Omar Chidiac, Sara Abdulkader, Wadha A Al Muftah, Cindy McKeon, Karsten Suhre, Dennis O. Mook-Kanamori

Research output: Contribution to journalArticle

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Abstract

Advanced glycation end products (AGEs) have been shown to be a predictor of cardiovascular risk in Caucasian subjects. In this study we examine whether the existing reference values are useable for non-Caucasian ethnicities. Furthermore, we assessed whether gender and smoking affect AGEs. Methods: AGEs were determined by a non-invasive method of skin auto-fluorescence (AF). AF was measured in 200 Arabs, 99 South Asians, 35 Filipinos and 14 subjects of other/mixed ethnicity in the Qatar Metabolomics Study on Diabetes (QMDiab). Using multivariate linear regression analysis and adjusting for age and type 2 diabetes, we assessed whether ethnicity, gender and smoking were associated with AF. Results: The mean AF was 2.27 arbitrary units (AU) (SD: 0.63). Arabs and Filipinos had a significant higher AF than the South Asian population (0.25 arbitrary units (AU) (95% CI: 0.11*0.39), p = 0.001 and 0.34 (95% CI: 0.13*0.55), p = 0.001 respectively). Also, AF was significantly higher in females (0.41 AU (95% CI: 0.29*0.53), p 0.001). AF associated with smoking (0.21 AU (95% CI: 0.01*0.41), p = 0.04) and increased with the number of pack-years smoked (p = 0.02). Conclusions: This study suggests that the existing reference values should take ethnicity, gender and smoking into account. Larger studies in specific ethnicities are necessary to create ethnic-and gender-specific reference values.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalDermato-Endocrinology
Volume5
Issue number2
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Advanced Glycosylation End Products
Fluorescence
Skin
Smoking
Reference Values
Qatar
Metabolomics
Type 2 Diabetes Mellitus
Linear Models
Regression Analysis
Population

Keywords

  • Advanced glycation endproducts
  • Epidemiology
  • Ethnicity
  • Gender differences
  • Skin auto-fluorescence
  • Smoking
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Dermatology

Cite this

Mook-Kanamori, M. J., El-Din Selim, M. M., Takiddin, A. H., Al-Homsi, H., Al-Mahmoud, K. A. S., Al-Obaidli, A., ... Mook-Kanamori, D. O. (2013). Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence. Dermato-Endocrinology, 5(2), 325-330. https://doi.org/10.4161/derm.26046

Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence. / Mook-Kanamori, Marjonneke J.; El-Din Selim, Mohammed M.; Takiddin, Ahmed H.; Al-Homsi, Hala; Al-Mahmoud, Khoulood A S; Al-Obaidli, Amina; Zirie, Mahmoud A.; Rowe, Jillian; Gherbi, Wafaa Sekkal; Chidiac, Omar; Abdulkader, Sara; Muftah, Wadha A Al; McKeon, Cindy; Suhre, Karsten; Mook-Kanamori, Dennis O.

In: Dermato-Endocrinology, Vol. 5, No. 2, 04.2013, p. 325-330.

Research output: Contribution to journalArticle

Mook-Kanamori, MJ, El-Din Selim, MM, Takiddin, AH, Al-Homsi, H, Al-Mahmoud, KAS, Al-Obaidli, A, Zirie, MA, Rowe, J, Gherbi, WS, Chidiac, O, Abdulkader, S, Muftah, WAA, McKeon, C, Suhre, K & Mook-Kanamori, DO 2013, 'Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence', Dermato-Endocrinology, vol. 5, no. 2, pp. 325-330. https://doi.org/10.4161/derm.26046
Mook-Kanamori MJ, El-Din Selim MM, Takiddin AH, Al-Homsi H, Al-Mahmoud KAS, Al-Obaidli A et al. Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence. Dermato-Endocrinology. 2013 Apr;5(2):325-330. https://doi.org/10.4161/derm.26046
Mook-Kanamori, Marjonneke J. ; El-Din Selim, Mohammed M. ; Takiddin, Ahmed H. ; Al-Homsi, Hala ; Al-Mahmoud, Khoulood A S ; Al-Obaidli, Amina ; Zirie, Mahmoud A. ; Rowe, Jillian ; Gherbi, Wafaa Sekkal ; Chidiac, Omar ; Abdulkader, Sara ; Muftah, Wadha A Al ; McKeon, Cindy ; Suhre, Karsten ; Mook-Kanamori, Dennis O. / Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence. In: Dermato-Endocrinology. 2013 ; Vol. 5, No. 2. pp. 325-330.
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AU - El-Din Selim, Mohammed M.

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AU - Al-Homsi, Hala

AU - Al-Mahmoud, Khoulood A S

AU - Al-Obaidli, Amina

AU - Zirie, Mahmoud A.

AU - Rowe, Jillian

AU - Gherbi, Wafaa Sekkal

AU - Chidiac, Omar

AU - Abdulkader, Sara

AU - Muftah, Wadha A Al

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AU - Mook-Kanamori, Dennis O.

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N2 - Advanced glycation end products (AGEs) have been shown to be a predictor of cardiovascular risk in Caucasian subjects. In this study we examine whether the existing reference values are useable for non-Caucasian ethnicities. Furthermore, we assessed whether gender and smoking affect AGEs. Methods: AGEs were determined by a non-invasive method of skin auto-fluorescence (AF). AF was measured in 200 Arabs, 99 South Asians, 35 Filipinos and 14 subjects of other/mixed ethnicity in the Qatar Metabolomics Study on Diabetes (QMDiab). Using multivariate linear regression analysis and adjusting for age and type 2 diabetes, we assessed whether ethnicity, gender and smoking were associated with AF. Results: The mean AF was 2.27 arbitrary units (AU) (SD: 0.63). Arabs and Filipinos had a significant higher AF than the South Asian population (0.25 arbitrary units (AU) (95% CI: 0.11*0.39), p = 0.001 and 0.34 (95% CI: 0.13*0.55), p = 0.001 respectively). Also, AF was significantly higher in females (0.41 AU (95% CI: 0.29*0.53), p 0.001). AF associated with smoking (0.21 AU (95% CI: 0.01*0.41), p = 0.04) and increased with the number of pack-years smoked (p = 0.02). Conclusions: This study suggests that the existing reference values should take ethnicity, gender and smoking into account. Larger studies in specific ethnicities are necessary to create ethnic-and gender-specific reference values.

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KW - Gender differences

KW - Skin auto-fluorescence

KW - Smoking

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