Estimating seroprevalence of herpes simplex virus type 1 among different Middle East and North African male populations residing in Qatar

Gheyath K. Nasrallah, Soha Dargham, Layla I. Mohammed, Laith Aburaddad

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

HSV-1 epidemiology in the Middle East and North Africa (MENA) remains poorly understood. Our study aimed to measure HSV-1 antibody prevalence (seroprevalence) and its age-distribution among select MENA populations residing in Qatar. Sera were collected from male blood donors attending Hamad Medical Corporation 2013-2015. A total of 2,077 sera were tested for anti-HSV-1 antibodies using HerpeSelect® 1 ELISA IgG kits (Focus Diagnostics, Cypress, CA). Robust Poisson regression was conducted to estimate adjusted infection prevalence ratios. Country-specific HSV-1 seroprevalence was estimated for 10 national populations: 97.5% among Egyptians, 92.6% among Yemenis, 90.7% among Sudanese, 88.5% among Syrians, 86.5% among Jordanians, 82.3% among Qataris, 81.4% among Iranians, 81.4% among Lebanese, 80.5% among Palestinians, and 77.0% among Pakistanis. Age-specific HSV-1 seroprevalence was estimated for Egypt, the Fertile Crescent (Iraq, Jordan, Lebanon, Palestine, and Syria), and Qatar. Seroprevalence increased with age among Fertile Crescent and Qatari nationals. Seroprevalence increased from 70.0% among those aged ≤ 24 years up to 98.0% among those aged ≥55 years among Fertile Crescent nationals. Seroprevalence was consistently above 90% for all ages among Egyptians. HSV-1 seroprevalence is high in MENA, though with some variation across countries. The seroprevalence appears to have declined among current young age cohorts compared to its levels a few decades ago.

Original languageEnglish
Pages (from-to)184-190
Number of pages7
JournalJournal of Medical Virology
Volume90
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Qatar
Middle East
Seroepidemiologic Studies
Human Herpesvirus 1
Northern Africa
Eastern Africa
Population
Cupressus
Syria
Lebanon
Iraq
Jordan
Antibodies
Egypt
Age Distribution
Blood Donors
Serum
Epidemiology
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay

Keywords

  • herpes
  • herpes simplex virus type 1
  • Middle East and North Africa
  • prevalence
  • sexually transmitted infection

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Estimating seroprevalence of herpes simplex virus type 1 among different Middle East and North African male populations residing in Qatar. / Nasrallah, Gheyath K.; Dargham, Soha; Mohammed, Layla I.; Aburaddad, Laith.

In: Journal of Medical Virology, Vol. 90, No. 1, 01.01.2018, p. 184-190.

Research output: Contribution to journalArticle

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