Epstein-Barr virus (EBV) status in colorectal cancer: a mini review

Shahinaz Bedri, Ali A. Sultan, Moussa Alkhalaf, Ala Eddin Al Moustafa, Semir Vranic

Research output: Contribution to journalReview article

Abstract

Epstein-Barr virus (EBV) is a well-characterized oncovirus, associated with several malignancies. The complex and heterogeneous nature of colorectal cancer (CRC) has led to many epidemiological causal associations with CRC. However, a direct causal link between microbial infections and CRC has not been established yet. Our review indicates that the current evidence for the presence and role in EBV in CRC is insufficient and contradictory. The design of the analyzed studies, sample size as well as methodology used for EBV detection varied markedly and consequently may not lead to meaningful conclusions. The presence of EBV in other colorectal tumors (lymphomas, smooth muscle tumors) is in line with their status at other anatomic locations and may have therapeutic implications with EBV-specific vaccines. On the other hand, studies exploring EBV in colorectal adenoma-carcinoma sequence and its molecular genetic characteristics are largely missing and may significantly contribute to a better understanding of the role of EBV in CRC.

Original languageEnglish
Pages (from-to)603-610
Number of pages8
JournalHuman Vaccines and Immunotherapeutics
Volume15
Issue number3
DOIs
Publication statusPublished - 4 Mar 2019

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Keywords

  • Colorectal cancer
  • Epstein-Barr virus
  • microbes
  • review

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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