Epstein-Barr virus DNA quantification and follow-up in Tunisian nasopharyngeal carcinoma patients

Elham Hassen, Karim Farhat, Sallouha Gabbouj, Noureddine Bouaouina, Hamdi Abdelaziz, Lotfi Chouchane

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The prognostic value of the Epstein-Barr virus (EBV) DNA load in sera of nasopharyngeal carcinoma (NPC) patients measured before any treatment, after treatment and before relapse was assessed. The real-time polymerase chain reaction was used to detect the viral load levels among 74 NPC subjects. Patients were followed up for a period going from 1 to 6 years (median 4 years). Before treatment, the EBV DNA load was correlated with lymph node involvement and advanced stages. After treatment, the viral load level declined significantly and patients presenting a viral load level lower than 1000 copies/ml showed a better overall survival (OS). Moreover, a significant result was found when the 6-year OS rates of patients having fewer or more than 15,000 copies/ml of viral load before relapse were compared. These results suggest that the EBV DNA load quantification after treatment may be a useful predictor of disease progression and survival.

Original languageEnglish
Pages (from-to)274-280
Number of pages7
JournalBiomarkers
Volume16
Issue number3
DOIs
Publication statusPublished - May 2011

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Keywords

  • EBV DNA load
  • NPC
  • prognosis
  • survivals

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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