Epigenetic impacts on neurodevelopment: Pathophysiological mechanisms and genetic modes of action

Farah R. Zahir, Carolyn J. Brown

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Disruptions of genes that are involved in epigenetic functions are known to be causative for several mental retardation/intellectual disability (MR/ID) syndromes. Recent work has highlighted genes with epigenetic functions as being implicated in autism spectrum disorders (ASDs) and schizophrenia (SCZ). The gene-environment interaction is an important factor of pathogenicity for these complex disorders. Epigenetic modifications offer a mechanism by which we can explain how the environment interacts with, and is able to dynamically regulate, the genome. This review aims to provide an overview of the role of epigenetic deregulation in the etiopathology for neurodevelopment disease.

Original languageEnglish
Pages (from-to)92R-100R
JournalPediatric Research
Volume69
Issue number5 PART 2
DOIs
Publication statusPublished - 1 May 2011

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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