Epigenetic impacts on neurodevelopment: Pathophysiological mechanisms and genetic modes of action

Farah R. Zahir, Carolyn J. Brown

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Disruptions of genes that are involved in epigenetic functions are known to be causative for several mental retardation/intellectual disability (MR/ID) syndromes. Recent work has highlighted genes with epigenetic functions as being implicated in autism spectrum disorders (ASDs) and schizophrenia (SCZ). The gene-environment interaction is an important factor of pathogenicity for these complex disorders. Epigenetic modifications offer a mechanism by which we can explain how the environment interacts with, and is able to dynamically regulate, the genome. This review aims to provide an overview of the role of epigenetic deregulation in the etiopathology for neurodevelopment disease.

Original languageEnglish
JournalPediatric Research
Volume69
Issue number5 PART 2
DOIs
Publication statusPublished - May 2011
Externally publishedYes

Fingerprint

Epigenomics
Intellectual Disability
Gene-Environment Interaction
Virulence Factors
Genes
Schizophrenia
Genome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Epigenetic impacts on neurodevelopment : Pathophysiological mechanisms and genetic modes of action. / Zahir, Farah R.; Brown, Carolyn J.

In: Pediatric Research, Vol. 69, No. 5 PART 2, 05.2011.

Research output: Contribution to journalArticle

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