Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients

Soha Dargham, Sumeja Zahirovic, Mohammed Hammoudeh, Samar Al Emadi, Basel K. Masri, Hussein Halabi, Humeira Badsha, Imad Uthman, Ziyad R. Mahfoud, Hadil Ashour, Wissam Gad El Haq, Karim Bayoumy, Marianthi Kapiri, Richa Saxena, Robert M. Plenge, Layla Kazkaz, Thurayya Arayssi

Research output: Contribution to journalArticle

Abstract

Objectives There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe the demographic characteristics, clinical profile, and treatment patterns of patients of Arab ancestry with RA. Methods This is a cross sectional study of 895 patients with established rheumatoid arthritis enrolled from five sites (Jordan, Lebanon, Qatar, Kingdom of Saudi Arabia (KSA), and United Arab Emirates). Demographic characteristics, clinical profile, and treatment patterns are compared between the five countries. Results The majority of our patients are women, have an average disease duration of 10 years, are married and non-smokers, with completed secondary education. We report a high (>80%) ever-use of methotrexate (MTX) and steroids among our RA population, while the ever-use of disease modifying anti-rheumatic drugs (DMARDs) and TNF-inhibitors average around 67% and 33%, respectively. There are variations in RA treatment use between the five country sites. Highest utilization of steroids is identified in Jordan and KSA (p-value < 0.001), while the highest ever-use of TNF-inhibitors is reported in KSA (p-value < 0.001). Conclusion Disparities in usage of RA treatments among Arab patients are noted across the five countries. National gross domestic product (GDP), as well as some other unique features in each country likely affect these. Developing treatment guidelines specific to this region could contribute in delivering standardized therapies to RA patients.

Original languageEnglish
Article numbere0208240
JournalPLoS One
Volume13
Issue number12
DOIs
Publication statusPublished - 1 Dec 2018

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Arabs
Epidemiology
rheumatoid arthritis
epidemiology
Rheumatoid Arthritis
Steroids
Antirheumatic Agents
Saudi Arabia
Methotrexate
Education
Jordan
sociodemographic characteristics
Therapeutics
steroids
Qatar
Demography
secondary education
United Arab Emirates
Gross Domestic Product
Lebanon

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients. / Dargham, Soha; Zahirovic, Sumeja; Hammoudeh, Mohammed; Emadi, Samar Al; Masri, Basel K.; Halabi, Hussein; Badsha, Humeira; Uthman, Imad; Mahfoud, Ziyad R.; Ashour, Hadil; Haq, Wissam Gad El; Bayoumy, Karim; Kapiri, Marianthi; Saxena, Richa; Plenge, Robert M.; Kazkaz, Layla; Arayssi, Thurayya.

In: PLoS One, Vol. 13, No. 12, e0208240, 01.12.2018.

Research output: Contribution to journalArticle

Dargham, S, Zahirovic, S, Hammoudeh, M, Emadi, SA, Masri, BK, Halabi, H, Badsha, H, Uthman, I, Mahfoud, ZR, Ashour, H, Haq, WGE, Bayoumy, K, Kapiri, M, Saxena, R, Plenge, RM, Kazkaz, L & Arayssi, T 2018, 'Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients', PLoS One, vol. 13, no. 12, e0208240. https://doi.org/10.1371/journal.pone.0208240
Dargham, Soha ; Zahirovic, Sumeja ; Hammoudeh, Mohammed ; Emadi, Samar Al ; Masri, Basel K. ; Halabi, Hussein ; Badsha, Humeira ; Uthman, Imad ; Mahfoud, Ziyad R. ; Ashour, Hadil ; Haq, Wissam Gad El ; Bayoumy, Karim ; Kapiri, Marianthi ; Saxena, Richa ; Plenge, Robert M. ; Kazkaz, Layla ; Arayssi, Thurayya. / Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients. In: PLoS One. 2018 ; Vol. 13, No. 12.
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abstract = "Objectives There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe the demographic characteristics, clinical profile, and treatment patterns of patients of Arab ancestry with RA. Methods This is a cross sectional study of 895 patients with established rheumatoid arthritis enrolled from five sites (Jordan, Lebanon, Qatar, Kingdom of Saudi Arabia (KSA), and United Arab Emirates). Demographic characteristics, clinical profile, and treatment patterns are compared between the five countries. Results The majority of our patients are women, have an average disease duration of 10 years, are married and non-smokers, with completed secondary education. We report a high (>80{\%}) ever-use of methotrexate (MTX) and steroids among our RA population, while the ever-use of disease modifying anti-rheumatic drugs (DMARDs) and TNF-inhibitors average around 67{\%} and 33{\%}, respectively. There are variations in RA treatment use between the five country sites. Highest utilization of steroids is identified in Jordan and KSA (p-value < 0.001), while the highest ever-use of TNF-inhibitors is reported in KSA (p-value < 0.001). Conclusion Disparities in usage of RA treatments among Arab patients are noted across the five countries. National gross domestic product (GDP), as well as some other unique features in each country likely affect these. Developing treatment guidelines specific to this region could contribute in delivering standardized therapies to RA patients.",
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AU - Zahirovic, Sumeja

AU - Hammoudeh, Mohammed

AU - Emadi, Samar Al

AU - Masri, Basel K.

AU - Halabi, Hussein

AU - Badsha, Humeira

AU - Uthman, Imad

AU - Mahfoud, Ziyad R.

AU - Ashour, Hadil

AU - Haq, Wissam Gad El

AU - Bayoumy, Karim

AU - Kapiri, Marianthi

AU - Saxena, Richa

AU - Plenge, Robert M.

AU - Kazkaz, Layla

AU - Arayssi, Thurayya

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N2 - Objectives There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe the demographic characteristics, clinical profile, and treatment patterns of patients of Arab ancestry with RA. Methods This is a cross sectional study of 895 patients with established rheumatoid arthritis enrolled from five sites (Jordan, Lebanon, Qatar, Kingdom of Saudi Arabia (KSA), and United Arab Emirates). Demographic characteristics, clinical profile, and treatment patterns are compared between the five countries. Results The majority of our patients are women, have an average disease duration of 10 years, are married and non-smokers, with completed secondary education. We report a high (>80%) ever-use of methotrexate (MTX) and steroids among our RA population, while the ever-use of disease modifying anti-rheumatic drugs (DMARDs) and TNF-inhibitors average around 67% and 33%, respectively. There are variations in RA treatment use between the five country sites. Highest utilization of steroids is identified in Jordan and KSA (p-value < 0.001), while the highest ever-use of TNF-inhibitors is reported in KSA (p-value < 0.001). Conclusion Disparities in usage of RA treatments among Arab patients are noted across the five countries. National gross domestic product (GDP), as well as some other unique features in each country likely affect these. Developing treatment guidelines specific to this region could contribute in delivering standardized therapies to RA patients.

AB - Objectives There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe the demographic characteristics, clinical profile, and treatment patterns of patients of Arab ancestry with RA. Methods This is a cross sectional study of 895 patients with established rheumatoid arthritis enrolled from five sites (Jordan, Lebanon, Qatar, Kingdom of Saudi Arabia (KSA), and United Arab Emirates). Demographic characteristics, clinical profile, and treatment patterns are compared between the five countries. Results The majority of our patients are women, have an average disease duration of 10 years, are married and non-smokers, with completed secondary education. We report a high (>80%) ever-use of methotrexate (MTX) and steroids among our RA population, while the ever-use of disease modifying anti-rheumatic drugs (DMARDs) and TNF-inhibitors average around 67% and 33%, respectively. There are variations in RA treatment use between the five country sites. Highest utilization of steroids is identified in Jordan and KSA (p-value < 0.001), while the highest ever-use of TNF-inhibitors is reported in KSA (p-value < 0.001). Conclusion Disparities in usage of RA treatments among Arab patients are noted across the five countries. National gross domestic product (GDP), as well as some other unique features in each country likely affect these. Developing treatment guidelines specific to this region could contribute in delivering standardized therapies to RA patients.

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