Environment impacts innate immune ontogeny

Mathieu Garand, Bing Cai, Tobias R. Kollmann

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Susceptibility to infection and response to vaccination differ between populations and as a function of age. The underlying mechanisms for this age- and population-dependent variation are not known. Specifically, it is unclear if these variations are due to differences in genetically encoded host programs or driven by environmental influences or a combination of both. To address the relationship between gene and environment regarding immune ontogeny, we determined the innate cytokine responses following PRR stimulation of blood mononuclear cells at birth, 1, and 2 yr of age in infants from Caucasian vs. Asian parents and were raised in the same city. At birth, we found that innate cytokine responses were significantly elevated in Asian compared with Caucasian infants. However, these differences waned and responses became more similar over the course of 1-2 yr of living in a similar environment. Our observations that innate response differences present at birth subsequently equalized rather than diverged suggest a key role for environmental effects common to both racial groups in shaping the innate immune responses early in life. Delineating the underlying environmental factors that modulate innate immune responses early in life could provide avenues for targeted beneficial immune modulation.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalInnate Immunity
Volume23
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Fingerprint

Parturition
Innate Immunity
Cytokines
Population
Blood Cells
Vaccination
Parents
Infection
Genes

Keywords

  • age
  • cytokine
  • Environment
  • ethnic
  • immunity
  • infants
  • innate
  • race
  • responses

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Molecular Biology
  • Cell Biology
  • Infectious Diseases

Cite this

Environment impacts innate immune ontogeny. / Garand, Mathieu; Cai, Bing; Kollmann, Tobias R.

In: Innate Immunity, Vol. 23, No. 1, 01.01.2017, p. 3-10.

Research output: Contribution to journalArticle

Garand, Mathieu ; Cai, Bing ; Kollmann, Tobias R. / Environment impacts innate immune ontogeny. In: Innate Immunity. 2017 ; Vol. 23, No. 1. pp. 3-10.
@article{983459dfb8f64874a0e9e4a745be6727,
title = "Environment impacts innate immune ontogeny",
abstract = "Susceptibility to infection and response to vaccination differ between populations and as a function of age. The underlying mechanisms for this age- and population-dependent variation are not known. Specifically, it is unclear if these variations are due to differences in genetically encoded host programs or driven by environmental influences or a combination of both. To address the relationship between gene and environment regarding immune ontogeny, we determined the innate cytokine responses following PRR stimulation of blood mononuclear cells at birth, 1, and 2 yr of age in infants from Caucasian vs. Asian parents and were raised in the same city. At birth, we found that innate cytokine responses were significantly elevated in Asian compared with Caucasian infants. However, these differences waned and responses became more similar over the course of 1-2 yr of living in a similar environment. Our observations that innate response differences present at birth subsequently equalized rather than diverged suggest a key role for environmental effects common to both racial groups in shaping the innate immune responses early in life. Delineating the underlying environmental factors that modulate innate immune responses early in life could provide avenues for targeted beneficial immune modulation.",
keywords = "age, cytokine, Environment, ethnic, immunity, infants, innate, race, responses",
author = "Mathieu Garand and Bing Cai and Kollmann, {Tobias R.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1177/1753425916671018",
language = "English",
volume = "23",
pages = "3--10",
journal = "Innate Immunity",
issn = "1753-4259",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Environment impacts innate immune ontogeny

AU - Garand, Mathieu

AU - Cai, Bing

AU - Kollmann, Tobias R.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Susceptibility to infection and response to vaccination differ between populations and as a function of age. The underlying mechanisms for this age- and population-dependent variation are not known. Specifically, it is unclear if these variations are due to differences in genetically encoded host programs or driven by environmental influences or a combination of both. To address the relationship between gene and environment regarding immune ontogeny, we determined the innate cytokine responses following PRR stimulation of blood mononuclear cells at birth, 1, and 2 yr of age in infants from Caucasian vs. Asian parents and were raised in the same city. At birth, we found that innate cytokine responses were significantly elevated in Asian compared with Caucasian infants. However, these differences waned and responses became more similar over the course of 1-2 yr of living in a similar environment. Our observations that innate response differences present at birth subsequently equalized rather than diverged suggest a key role for environmental effects common to both racial groups in shaping the innate immune responses early in life. Delineating the underlying environmental factors that modulate innate immune responses early in life could provide avenues for targeted beneficial immune modulation.

AB - Susceptibility to infection and response to vaccination differ between populations and as a function of age. The underlying mechanisms for this age- and population-dependent variation are not known. Specifically, it is unclear if these variations are due to differences in genetically encoded host programs or driven by environmental influences or a combination of both. To address the relationship between gene and environment regarding immune ontogeny, we determined the innate cytokine responses following PRR stimulation of blood mononuclear cells at birth, 1, and 2 yr of age in infants from Caucasian vs. Asian parents and were raised in the same city. At birth, we found that innate cytokine responses were significantly elevated in Asian compared with Caucasian infants. However, these differences waned and responses became more similar over the course of 1-2 yr of living in a similar environment. Our observations that innate response differences present at birth subsequently equalized rather than diverged suggest a key role for environmental effects common to both racial groups in shaping the innate immune responses early in life. Delineating the underlying environmental factors that modulate innate immune responses early in life could provide avenues for targeted beneficial immune modulation.

KW - age

KW - cytokine

KW - Environment

KW - ethnic

KW - immunity

KW - infants

KW - innate

KW - race

KW - responses

UR - http://www.scopus.com/inward/record.url?scp=85006747267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006747267&partnerID=8YFLogxK

U2 - 10.1177/1753425916671018

DO - 10.1177/1753425916671018

M3 - Article

C2 - 27697850

AN - SCOPUS:85006747267

VL - 23

SP - 3

EP - 10

JO - Innate Immunity

JF - Innate Immunity

SN - 1753-4259

IS - 1

ER -