Ensembl regulation resources

Daniel R. Zerbino, Nathan Johnson, Thomas Juetteman, Dan Sheppard, Steven P. Wilder, Ilias Lavidas, Michael Nuhn, Emily Perry, Quentin Raffaillac-Desfosses, Daniel Sobral, Damian Keefe, Stefan Gräf, Ikhlak Ahmed, Rhoda Kinsella, Bethan Pritchard, Simon Brent, Ridwan Amode, Anne Parker, Steven Trevanion, Ewan Birney & 2 others Ian Dunham, Paul Flicek

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

New experimental techniques in epigenomics allow researchers to assay a diversity of highly dynamic features such as histone marks, DNA modifications or chromatin structure. The study of their fluctuations should provide insights into gene expression regulation, cell differentiation and disease. The Ensembl project collects and maintains the Ensembl regulation data resources on epigenetic marks, transcription factor binding and DNA methylation for human and mouse, as well as microarray probe mappings and annotations for a variety of chordate genomes. From this data, we produce a functional annotation of the regulatory elements along the human and mouse genomes with plans to expand to other species as data becomes available. Starting from well-studied cell lines, we will progressively expand our library of measurements to a greater variety of samples. Ensembl's regulation resources provide a central and easy-to-query repository for reference epigenomes.

Original languageEnglish
Article numberbav119
JournalDatabase
Volume2016
DOIs
Publication statusPublished - 1 Jan 2016

Fingerprint

Epigenomics
epigenetics
Gene expression regulation
Histone Code
Genes
Chordata
Transcription factors
genome
mice
gene expression regulation
Gene Expression Regulation
Human Genome
DNA methylation
DNA Methylation
Microarrays
histones
cell differentiation
Histones
Libraries
Chromatin

ASJC Scopus subject areas

  • Information Systems
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Zerbino, D. R., Johnson, N., Juetteman, T., Sheppard, D., Wilder, S. P., Lavidas, I., ... Flicek, P. (2016). Ensembl regulation resources. Database, 2016, [bav119]. https://doi.org/10.1093/database/bav119

Ensembl regulation resources. / Zerbino, Daniel R.; Johnson, Nathan; Juetteman, Thomas; Sheppard, Dan; Wilder, Steven P.; Lavidas, Ilias; Nuhn, Michael; Perry, Emily; Raffaillac-Desfosses, Quentin; Sobral, Daniel; Keefe, Damian; Gräf, Stefan; Ahmed, Ikhlak; Kinsella, Rhoda; Pritchard, Bethan; Brent, Simon; Amode, Ridwan; Parker, Anne; Trevanion, Steven; Birney, Ewan; Dunham, Ian; Flicek, Paul.

In: Database, Vol. 2016, bav119, 01.01.2016.

Research output: Contribution to journalArticle

Zerbino, DR, Johnson, N, Juetteman, T, Sheppard, D, Wilder, SP, Lavidas, I, Nuhn, M, Perry, E, Raffaillac-Desfosses, Q, Sobral, D, Keefe, D, Gräf, S, Ahmed, I, Kinsella, R, Pritchard, B, Brent, S, Amode, R, Parker, A, Trevanion, S, Birney, E, Dunham, I & Flicek, P 2016, 'Ensembl regulation resources', Database, vol. 2016, bav119. https://doi.org/10.1093/database/bav119
Zerbino DR, Johnson N, Juetteman T, Sheppard D, Wilder SP, Lavidas I et al. Ensembl regulation resources. Database. 2016 Jan 1;2016. bav119. https://doi.org/10.1093/database/bav119
Zerbino, Daniel R. ; Johnson, Nathan ; Juetteman, Thomas ; Sheppard, Dan ; Wilder, Steven P. ; Lavidas, Ilias ; Nuhn, Michael ; Perry, Emily ; Raffaillac-Desfosses, Quentin ; Sobral, Daniel ; Keefe, Damian ; Gräf, Stefan ; Ahmed, Ikhlak ; Kinsella, Rhoda ; Pritchard, Bethan ; Brent, Simon ; Amode, Ridwan ; Parker, Anne ; Trevanion, Steven ; Birney, Ewan ; Dunham, Ian ; Flicek, Paul. / Ensembl regulation resources. In: Database. 2016 ; Vol. 2016.
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