Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin

Howard Lou; Ronald Crystal; Philip L. Leopold

doi:10.1016/j.ymthe.2005.01.009

Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin

Howard Lou, Ronald Crystal, Philip L. Leopold

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

The role of Sonic hedgehog (Shh) as a morphogen in diverse developmental settings depends on covalent addition of cholesterol. In this study, expression of Shh lacking cholesterol stimulated hair growth with greater efficacy than native Shh, suggesting that Shh acts as a chemokine rather than a morphogen in this postnatal role. Thus, a structural modification that renders a morphogen ineffective in developmental models may have distinct advantages for postnatal applications.

Original language	English
Pages (from-to)	575-578
Number of pages	4
Journal	Molecular Therapy
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.ymthe.2005.01.009
Publication status	Published - 1 Sep 2005
Externally published	Yes

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Keywords

Adenoviridae
Gene therapy
Genetic vectors
Hair follicle
Keratinocytes

ASJC Scopus subject areas

Molecular Biology

Cite this

Lou, H., Crystal, R., & Leopold, P. L. (2005). Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin. Molecular Therapy, 12(3), 575-578. https://doi.org/10.1016/j.ymthe.2005.01.009

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Access to Document

10.1016/j.ymthe.2005.01.009