Abstract
The role of Sonic hedgehog (Shh) as a morphogen in diverse developmental settings depends on covalent addition of cholesterol. In this study, expression of Shh lacking cholesterol stimulated hair growth with greater efficacy than native Shh, suggesting that Shh acts as a chemokine rather than a morphogen in this postnatal role. Thus, a structural modification that renders a morphogen ineffective in developmental models may have distinct advantages for postnatal applications.
| Original language | English |
|---|---|
| Pages (from-to) | 575-578 |
| Number of pages | 4 |
| Journal | Molecular Therapy |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Sep 2005 |
| Externally published | Yes |
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Keywords
- Adenoviridae
- Gene therapy
- Genetic vectors
- Hair follicle
- Keratinocytes
ASJC Scopus subject areas
- Molecular Biology
Cite this
Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin. / Lou, Howard; Crystal, Ronald; Leopold, Philip L.
In: Molecular Therapy, Vol. 12, No. 3, 01.09.2005, p. 575-578.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin
AU - Lou, Howard
AU - Crystal, Ronald
AU - Leopold, Philip L.
PY - 2005/9/1
Y1 - 2005/9/1
N2 - The role of Sonic hedgehog (Shh) as a morphogen in diverse developmental settings depends on covalent addition of cholesterol. In this study, expression of Shh lacking cholesterol stimulated hair growth with greater efficacy than native Shh, suggesting that Shh acts as a chemokine rather than a morphogen in this postnatal role. Thus, a structural modification that renders a morphogen ineffective in developmental models may have distinct advantages for postnatal applications.
AB - The role of Sonic hedgehog (Shh) as a morphogen in diverse developmental settings depends on covalent addition of cholesterol. In this study, expression of Shh lacking cholesterol stimulated hair growth with greater efficacy than native Shh, suggesting that Shh acts as a chemokine rather than a morphogen in this postnatal role. Thus, a structural modification that renders a morphogen ineffective in developmental models may have distinct advantages for postnatal applications.
KW - Adenoviridae
KW - Gene therapy
KW - Genetic vectors
KW - Hair follicle
KW - Keratinocytes
UR - http://www.scopus.com/inward/record.url?scp=23844458442&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23844458442&partnerID=8YFLogxK
U2 - 10.1016/j.ymthe.2005.01.009
DO - 10.1016/j.ymthe.2005.01.009
M3 - Article
C2 - 15987672
AN - SCOPUS:23844458442
VL - 12
SP - 575
EP - 578
JO - Molecular Therapy
JF - Molecular Therapy
SN - 1525-0016
IS - 3
ER -