Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin

Howard Lou, Ronald G. Crystal, Philip L. Leopold

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The role of Sonic hedgehog (Shh) as a morphogen in diverse developmental settings depends on covalent addition of cholesterol. In this study, expression of Shh lacking cholesterol stimulated hair growth with greater efficacy than native Shh, suggesting that Shh acts as a chemokine rather than a morphogen in this postnatal role. Thus, a structural modification that renders a morphogen ineffective in developmental models may have distinct advantages for postnatal applications.

Original languageEnglish
Pages (from-to)575-578
Number of pages4
JournalMolecular Therapy
Volume12
Issue number3
DOIs
Publication statusPublished - 1 Sep 2005

Keywords

  • Adenoviridae
  • Gene therapy
  • Genetic vectors
  • Hair follicle
  • Keratinocytes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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