Enhanced bioavailability of eicosapentaenoic acid from fish oil after encapsulation within plant spore exines as microcapsules

Ammar Wakil, Grahame MacKenzie, Alberto Diego-Taboada, J. Gordon Bell, Stephen Atkin

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Benefits of eicosapentaenoic acid (EPA) can be enhanced by raising their bioavailability through microencapsulation. Pollen can be emptied to form hollow shells, known as exines, and then used to encapsulate material, such as oils in a dry powder form. Six healthy volunteers ingested 4.6 g of fish oil containing 20% EPA in the form of ethyl ester first alone and then as 1:1 microencapsulated powder of exines and fish oil. Serum bioavailability of EPA was measured by area under curve (AUC0-24). The mean AUC 0-24 of EPA from ethyl ester with exine (M = 19.7, SD = 4.3) was significantly higher than ethyl ester without exines (M = 2, SD = 1.4, p < 0.01).The bioavailability of EPA is enhanced by encapsulation by pollen exines.

Original languageEnglish
Pages (from-to)645-649
Number of pages5
JournalLipids
Volume45
Issue number7
DOIs
Publication statusPublished - Jul 2010
Externally publishedYes

Fingerprint

Eicosapentaenoic Acid
Fish Oils
Spores
Encapsulation
Biological Availability
Capsules
Pollen
Powders
Area Under Curve
Esters
Microencapsulation
Drug Compounding
Healthy Volunteers
Oils
Serum

Keywords

  • Bioavailability
  • Eicosapentaenoic acid
  • Exines
  • Microencapsulation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Organic Chemistry
  • Medicine(all)

Cite this

Enhanced bioavailability of eicosapentaenoic acid from fish oil after encapsulation within plant spore exines as microcapsules. / Wakil, Ammar; MacKenzie, Grahame; Diego-Taboada, Alberto; Bell, J. Gordon; Atkin, Stephen.

In: Lipids, Vol. 45, No. 7, 07.2010, p. 645-649.

Research output: Contribution to journalArticle

Wakil, Ammar ; MacKenzie, Grahame ; Diego-Taboada, Alberto ; Bell, J. Gordon ; Atkin, Stephen. / Enhanced bioavailability of eicosapentaenoic acid from fish oil after encapsulation within plant spore exines as microcapsules. In: Lipids. 2010 ; Vol. 45, No. 7. pp. 645-649.
@article{cec426fa8d3e442496185a26eda5e90a,
title = "Enhanced bioavailability of eicosapentaenoic acid from fish oil after encapsulation within plant spore exines as microcapsules",
abstract = "Benefits of eicosapentaenoic acid (EPA) can be enhanced by raising their bioavailability through microencapsulation. Pollen can be emptied to form hollow shells, known as exines, and then used to encapsulate material, such as oils in a dry powder form. Six healthy volunteers ingested 4.6 g of fish oil containing 20{\%} EPA in the form of ethyl ester first alone and then as 1:1 microencapsulated powder of exines and fish oil. Serum bioavailability of EPA was measured by area under curve (AUC0-24). The mean AUC 0-24 of EPA from ethyl ester with exine (M = 19.7, SD = 4.3) was significantly higher than ethyl ester without exines (M = 2, SD = 1.4, p < 0.01).The bioavailability of EPA is enhanced by encapsulation by pollen exines.",
keywords = "Bioavailability, Eicosapentaenoic acid, Exines, Microencapsulation",
author = "Ammar Wakil and Grahame MacKenzie and Alberto Diego-Taboada and Bell, {J. Gordon} and Stephen Atkin",
year = "2010",
month = "7",
doi = "10.1007/s11745-010-3427-y",
language = "English",
volume = "45",
pages = "645--649",
journal = "Lipids",
issn = "0024-4201",
publisher = "Springer Verlag",
number = "7",

}

TY - JOUR

T1 - Enhanced bioavailability of eicosapentaenoic acid from fish oil after encapsulation within plant spore exines as microcapsules

AU - Wakil, Ammar

AU - MacKenzie, Grahame

AU - Diego-Taboada, Alberto

AU - Bell, J. Gordon

AU - Atkin, Stephen

PY - 2010/7

Y1 - 2010/7

N2 - Benefits of eicosapentaenoic acid (EPA) can be enhanced by raising their bioavailability through microencapsulation. Pollen can be emptied to form hollow shells, known as exines, and then used to encapsulate material, such as oils in a dry powder form. Six healthy volunteers ingested 4.6 g of fish oil containing 20% EPA in the form of ethyl ester first alone and then as 1:1 microencapsulated powder of exines and fish oil. Serum bioavailability of EPA was measured by area under curve (AUC0-24). The mean AUC 0-24 of EPA from ethyl ester with exine (M = 19.7, SD = 4.3) was significantly higher than ethyl ester without exines (M = 2, SD = 1.4, p < 0.01).The bioavailability of EPA is enhanced by encapsulation by pollen exines.

AB - Benefits of eicosapentaenoic acid (EPA) can be enhanced by raising their bioavailability through microencapsulation. Pollen can be emptied to form hollow shells, known as exines, and then used to encapsulate material, such as oils in a dry powder form. Six healthy volunteers ingested 4.6 g of fish oil containing 20% EPA in the form of ethyl ester first alone and then as 1:1 microencapsulated powder of exines and fish oil. Serum bioavailability of EPA was measured by area under curve (AUC0-24). The mean AUC 0-24 of EPA from ethyl ester with exine (M = 19.7, SD = 4.3) was significantly higher than ethyl ester without exines (M = 2, SD = 1.4, p < 0.01).The bioavailability of EPA is enhanced by encapsulation by pollen exines.

KW - Bioavailability

KW - Eicosapentaenoic acid

KW - Exines

KW - Microencapsulation

UR - http://www.scopus.com/inward/record.url?scp=77955661659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955661659&partnerID=8YFLogxK

U2 - 10.1007/s11745-010-3427-y

DO - 10.1007/s11745-010-3427-y

M3 - Article

VL - 45

SP - 645

EP - 649

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 7

ER -