Endothelium-dependent hyperpolarization of vascular smooth muscle: Role for a non-nitric oxide synthase product

Gareth J. Waldron, Hui Dong, William C. Cole, Christopher Triggle

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

There is now a considerable evidence that indicates that there is non-NO/prostanoid mediated vasodilation/hyperpolarization mechanism in a variety of blood vessels from different species. It is argued that a factor, EDHF, is responsible for mediating these cellular events and, like NO, EDHF is synthesized and released, in a Ca2+-dependent manner, from endothelial cells and activates vascular K+ channel (s) with the predominant evidence suggesting K(Ca) (iberiotoxin and/or apamin sensitive) though this remains to be absolutely confirmed. A number of studies also indicate that a cytochrome P-450 metabolite of arachidonic acid, namely an epoxyeicosatrienoic acid, may serve as the chemical messenger between endothelial and vascular smooth muscle cells. Evidence confirming that there is chemical transmission between endothelial and vascular smooth muscle cells is, however, minimal. Although significant progress has been recently made, much needs to be discovered concerning the nature, synthesis, release, vascular effects as well as the role of EDHF in normal and diseased vascular tissue.

Original languageEnglish
Pages (from-to)3-7
Number of pages5
JournalActa Pharmacologica Sinica
Volume17
Issue number1
Publication statusPublished - Jan 1996
Externally publishedYes

Fingerprint

Vascular Smooth Muscle
Oxides
Endothelium
Muscle
Smooth Muscle Myocytes
Blood Vessels
Cells
Apamin
Endothelial cells
Blood vessels
Metabolites
Vascular Diseases
Arachidonic Acid
Vasodilation
Cytochrome P-450 Enzyme System
Prostaglandins
Endothelial Cells
Tissue
Acids
endothelium-dependent hyperpolarization factor

Keywords

  • calcium
  • cytochrome P-450
  • endothelium
  • endothelium-derived hyperpolarization factor
  • endothelium-derived relaxing factor
  • nitric oxide
  • potassium channels
  • vascular smooth muscle

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmacology

Cite this

Endothelium-dependent hyperpolarization of vascular smooth muscle : Role for a non-nitric oxide synthase product. / Waldron, Gareth J.; Dong, Hui; Cole, William C.; Triggle, Christopher.

In: Acta Pharmacologica Sinica, Vol. 17, No. 1, 01.1996, p. 3-7.

Research output: Contribution to journalReview article

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