Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins

Lawrence Ko, Andrew Maitland, Paul W.M. Fedak, Aaron S. Dumont, Mitesh Badiwala, Fina Lovren, Christopher Triggle, Todd J. Anderson, Vivek Rao, Subodh Verma

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background. Angiotensin II and endothelin-1 are potent endothelium-derived contracting factors. The effects of acute endothelin antagonism on endothelial function in saphenous vein from patients treated with and without angiotensin-converting enzyme inhibitors were compared. Methods. Vascular segments of saphenous vein were obtained perioperatively from 14 patients on angiotensin-converting enzyme inhibitors and 29 controls. In vitro endothelium-dependent and -independent responses to acetylcholine and sodium nitroprusside were assessed by constructing isometric dose-response curves in precontracted rings in the presence and absence of bosentan (endothelinA/B receptor antagonist) and BQ-123 (endothelinA antagonist) using isolated organ baths. Percent maximum relaxation and sensitivity were compared between interventions. Results. Endothelium-dependent relaxation to acetylcholine was augmented in the angiotensin-converting enzyme inhibitor-treated group (p < 0.005). Both specific and mixed endothelin receptor blockade improved acetylcholine-mediated relaxation in the angiotensin-converting enzyme inhibitor-treated and untreated groups (p < 0.02). The effects of these antagonists were endothelium specific as endothelium-independent responses to sodium nitroprusside remain unaltered. Conclusions. These data demonstrate that (1) chronic angiotensin-converting enzyme inhibition improves endothelial function in saphenous veins, and (2) this effect can be further augmented by acute endothelin blockade. These data suggest that antagonism of both angiotensin II and endothelin may be important in attenuating saphenous vein arteriosclerosis.

Original languageEnglish
Pages (from-to)1185-1188
Number of pages4
JournalAnnals of Thoracic Surgery
Volume73
Issue number4
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Endothelins
Saphenous Vein
Angiotensin-Converting Enzyme Inhibitors
Endothelium
Acetylcholine
Nitroprusside
Angiotensin II
Endothelin Receptors
Arteriosclerosis
Endothelin-1
Peptidyl-Dipeptidase A
Baths
Blood Vessels

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Ko, L., Maitland, A., Fedak, P. W. M., Dumont, A. S., Badiwala, M., Lovren, F., ... Verma, S. (2002). Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins. Annals of Thoracic Surgery, 73(4), 1185-1188. https://doi.org/10.1016/S0003-4975(01)03605-0

Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins. / Ko, Lawrence; Maitland, Andrew; Fedak, Paul W.M.; Dumont, Aaron S.; Badiwala, Mitesh; Lovren, Fina; Triggle, Christopher; Anderson, Todd J.; Rao, Vivek; Verma, Subodh.

In: Annals of Thoracic Surgery, Vol. 73, No. 4, 2002, p. 1185-1188.

Research output: Contribution to journalArticle

Ko, L, Maitland, A, Fedak, PWM, Dumont, AS, Badiwala, M, Lovren, F, Triggle, C, Anderson, TJ, Rao, V & Verma, S 2002, 'Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins', Annals of Thoracic Surgery, vol. 73, no. 4, pp. 1185-1188. https://doi.org/10.1016/S0003-4975(01)03605-0
Ko, Lawrence ; Maitland, Andrew ; Fedak, Paul W.M. ; Dumont, Aaron S. ; Badiwala, Mitesh ; Lovren, Fina ; Triggle, Christopher ; Anderson, Todd J. ; Rao, Vivek ; Verma, Subodh. / Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins. In: Annals of Thoracic Surgery. 2002 ; Vol. 73, No. 4. pp. 1185-1188.
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AU - Fedak, Paul W.M.

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AU - Badiwala, Mitesh

AU - Lovren, Fina

AU - Triggle, Christopher

AU - Anderson, Todd J.

AU - Rao, Vivek

AU - Verma, Subodh

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