Endothelial Fenestration of the Alveolar Capillaries in Interstitial Fibrotic Lung Diseases

Oichi Kawanami, Kiyoshi Matsuda, Hirohide Yoneyama, Victor J. Ferrans, Ronald Crystal

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A light and electron microscopy study was performed on endothelial cells of alveolar capillaries in biopsied lung tissues obtained from 28 patients with interstitial fibrotic lung diseases, including idiopathic pulmonary fibrosis, sar‐coidosis, hypersensitivity pneumonitis, chronic eosinophilic pneumonia, collagen vascular diseases and acute interstitial pneumonia. In the relatively early stages of acute interstitial pneumonia, hypersensitivity pneumonitis and other diseases, the cytoplasms of the endothelial cells appeared swollen and electron‐lucent and occasionally showed degeneration and necrosis. Although mitosis was not evident in the endothelium at any disease stage, some capillary endothelial cells showed regeneration. Furthermore, although rarely, they showed obvious phenotypic transformation into diaphragmed fenestrae in some limited segments of fibrotic lungs in the 20 of the 28 patients examined. The frequency of endothelial fenestration seemed to be correlated with the degree of interstitial fibrosis along the alveolar walls. In such fibrotic lung tissues, cuboidal metaplastic cells of bronchiolar origin proliferated on the luminal side. The mechanism of endothelial fenestration in the alveolar capillaries is assumed to be comparable with cuboidal metaplasia of alveolar epithelial cells. The alveolar capillary endothelium is recruited from the bronchiolar capillaries via bronchopul‐monary anastomoses unless endothelial repair occurs in situ. Regenerating endothelial cells move into the alveolar capillary tubes along the remnant sleeves of the basement membrane. New endothelial processes finally display their original fenestrated structure while secreting irregular fragments of basement membrane during implantation in the capillary beds. Acta Pathol Jpn 42: 177– 184, 1992.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalPathology International
Volume42
Issue number3
DOIs
Publication statusPublished - 1 Jan 1992
Externally publishedYes

Fingerprint

Interstitial Lung Diseases
Endothelial Cells
Extrinsic Allergic Alveolitis
Basement Membrane
Lung
Pulmonary Sarcoidosis
Alveolar Epithelial Cells
Collagen Diseases
Idiopathic Pulmonary Fibrosis
Vascular Endothelium
Metaplasia
Vascular Diseases
Mitosis
Endothelium
Regeneration
Electron Microscopy
Cytoplasm
Fibrosis
Necrosis
Light

Keywords

  • Alveolar capillary
  • Bronchial circulation
  • Capillary endothelium
  • Diaphragmed fenestra
  • Endothelium

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Endothelial Fenestration of the Alveolar Capillaries in Interstitial Fibrotic Lung Diseases. / Kawanami, Oichi; Matsuda, Kiyoshi; Yoneyama, Hirohide; Ferrans, Victor J.; Crystal, Ronald.

In: Pathology International, Vol. 42, No. 3, 01.01.1992, p. 177-184.

Research output: Contribution to journalArticle

Kawanami, Oichi ; Matsuda, Kiyoshi ; Yoneyama, Hirohide ; Ferrans, Victor J. ; Crystal, Ronald. / Endothelial Fenestration of the Alveolar Capillaries in Interstitial Fibrotic Lung Diseases. In: Pathology International. 1992 ; Vol. 42, No. 3. pp. 177-184.
@article{b9eb69582dbd4f87958976f10fd65652,
title = "Endothelial Fenestration of the Alveolar Capillaries in Interstitial Fibrotic Lung Diseases",
abstract = "A light and electron microscopy study was performed on endothelial cells of alveolar capillaries in biopsied lung tissues obtained from 28 patients with interstitial fibrotic lung diseases, including idiopathic pulmonary fibrosis, sar‐coidosis, hypersensitivity pneumonitis, chronic eosinophilic pneumonia, collagen vascular diseases and acute interstitial pneumonia. In the relatively early stages of acute interstitial pneumonia, hypersensitivity pneumonitis and other diseases, the cytoplasms of the endothelial cells appeared swollen and electron‐lucent and occasionally showed degeneration and necrosis. Although mitosis was not evident in the endothelium at any disease stage, some capillary endothelial cells showed regeneration. Furthermore, although rarely, they showed obvious phenotypic transformation into diaphragmed fenestrae in some limited segments of fibrotic lungs in the 20 of the 28 patients examined. The frequency of endothelial fenestration seemed to be correlated with the degree of interstitial fibrosis along the alveolar walls. In such fibrotic lung tissues, cuboidal metaplastic cells of bronchiolar origin proliferated on the luminal side. The mechanism of endothelial fenestration in the alveolar capillaries is assumed to be comparable with cuboidal metaplasia of alveolar epithelial cells. The alveolar capillary endothelium is recruited from the bronchiolar capillaries via bronchopul‐monary anastomoses unless endothelial repair occurs in situ. Regenerating endothelial cells move into the alveolar capillary tubes along the remnant sleeves of the basement membrane. New endothelial processes finally display their original fenestrated structure while secreting irregular fragments of basement membrane during implantation in the capillary beds. Acta Pathol Jpn 42: 177– 184, 1992.",
keywords = "Alveolar capillary, Bronchial circulation, Capillary endothelium, Diaphragmed fenestra, Endothelium",
author = "Oichi Kawanami and Kiyoshi Matsuda and Hirohide Yoneyama and Ferrans, {Victor J.} and Ronald Crystal",
year = "1992",
month = "1",
day = "1",
doi = "10.1111/j.1440-1827.1992.tb01669.x",
language = "English",
volume = "42",
pages = "177--184",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Endothelial Fenestration of the Alveolar Capillaries in Interstitial Fibrotic Lung Diseases

AU - Kawanami, Oichi

AU - Matsuda, Kiyoshi

AU - Yoneyama, Hirohide

AU - Ferrans, Victor J.

AU - Crystal, Ronald

PY - 1992/1/1

Y1 - 1992/1/1

N2 - A light and electron microscopy study was performed on endothelial cells of alveolar capillaries in biopsied lung tissues obtained from 28 patients with interstitial fibrotic lung diseases, including idiopathic pulmonary fibrosis, sar‐coidosis, hypersensitivity pneumonitis, chronic eosinophilic pneumonia, collagen vascular diseases and acute interstitial pneumonia. In the relatively early stages of acute interstitial pneumonia, hypersensitivity pneumonitis and other diseases, the cytoplasms of the endothelial cells appeared swollen and electron‐lucent and occasionally showed degeneration and necrosis. Although mitosis was not evident in the endothelium at any disease stage, some capillary endothelial cells showed regeneration. Furthermore, although rarely, they showed obvious phenotypic transformation into diaphragmed fenestrae in some limited segments of fibrotic lungs in the 20 of the 28 patients examined. The frequency of endothelial fenestration seemed to be correlated with the degree of interstitial fibrosis along the alveolar walls. In such fibrotic lung tissues, cuboidal metaplastic cells of bronchiolar origin proliferated on the luminal side. The mechanism of endothelial fenestration in the alveolar capillaries is assumed to be comparable with cuboidal metaplasia of alveolar epithelial cells. The alveolar capillary endothelium is recruited from the bronchiolar capillaries via bronchopul‐monary anastomoses unless endothelial repair occurs in situ. Regenerating endothelial cells move into the alveolar capillary tubes along the remnant sleeves of the basement membrane. New endothelial processes finally display their original fenestrated structure while secreting irregular fragments of basement membrane during implantation in the capillary beds. Acta Pathol Jpn 42: 177– 184, 1992.

AB - A light and electron microscopy study was performed on endothelial cells of alveolar capillaries in biopsied lung tissues obtained from 28 patients with interstitial fibrotic lung diseases, including idiopathic pulmonary fibrosis, sar‐coidosis, hypersensitivity pneumonitis, chronic eosinophilic pneumonia, collagen vascular diseases and acute interstitial pneumonia. In the relatively early stages of acute interstitial pneumonia, hypersensitivity pneumonitis and other diseases, the cytoplasms of the endothelial cells appeared swollen and electron‐lucent and occasionally showed degeneration and necrosis. Although mitosis was not evident in the endothelium at any disease stage, some capillary endothelial cells showed regeneration. Furthermore, although rarely, they showed obvious phenotypic transformation into diaphragmed fenestrae in some limited segments of fibrotic lungs in the 20 of the 28 patients examined. The frequency of endothelial fenestration seemed to be correlated with the degree of interstitial fibrosis along the alveolar walls. In such fibrotic lung tissues, cuboidal metaplastic cells of bronchiolar origin proliferated on the luminal side. The mechanism of endothelial fenestration in the alveolar capillaries is assumed to be comparable with cuboidal metaplasia of alveolar epithelial cells. The alveolar capillary endothelium is recruited from the bronchiolar capillaries via bronchopul‐monary anastomoses unless endothelial repair occurs in situ. Regenerating endothelial cells move into the alveolar capillary tubes along the remnant sleeves of the basement membrane. New endothelial processes finally display their original fenestrated structure while secreting irregular fragments of basement membrane during implantation in the capillary beds. Acta Pathol Jpn 42: 177– 184, 1992.

KW - Alveolar capillary

KW - Bronchial circulation

KW - Capillary endothelium

KW - Diaphragmed fenestra

KW - Endothelium

UR - http://www.scopus.com/inward/record.url?scp=0026594790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026594790&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1827.1992.tb01669.x

DO - 10.1111/j.1440-1827.1992.tb01669.x

M3 - Article

C2 - 1570740

AN - SCOPUS:0026594790

VL - 42

SP - 177

EP - 184

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 3

ER -