Endoneurial capillary abnormalities presage deterioration of glucose tolerance and accompany peripheral neuropathy in man

Soley Thrainsdottir, Rayaz Malik, Lars B. Dahlin, Peter Wiksell, Karl F. Eriksson, Ingmar Rosén, Jesper Petersson, Douglas A. Greene, Göran Sundkvist

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Abstract

To explore whether microangiopathy is associated with disturbed glucose tolerance and peripheral neuropathy, we assessed endoneurial capillary morphology in sural nerve biopsies from men with diabetes, impaired glucose tolerance (IGT), and normal glucose tolerance (NGT). Baseline morphology was related to glucose tolerance and neuropathy at baseline and at follow-up 6 years later. Capillary density (in number per millimeters squared) at baseline was higher in subjects with diabetes (n = 10) compared with those with NGT (n = 5) at follow-up (median [interquartile range]) (86.0 [24.3] vs. 54.9 [17.1]; P = 0.0200) and in those progressing from IGT to diabetes (n = 4) compared with those with persistent IGT (n = 4) (86.7 [25.2] vs. 54.1 [14.6]; P = 0.0433). The capillary luminal area (in micrometers squared) was lower in subjects with NGT progressing to IGT (n = 2) or subjects with IGT progressing to diabetes (n =3) compared with subjects with constant NGT (n = 6) or constant IGT (n = 4) (11.9 [2.4] vs. 20.8 [7.8]; P = 0.0201). The capillary basement membrane area (in micrometers squared) was increased in patients with peripheral neuropathy (n = 10) compared with those without (n = 7) (114.6 [68.8] vs. 75.3 [28.7]; P = 0.0084). In conclusion, increased capillary density was associated with current or future diabetes, decreased capillary luminal area with future deterioration in glucose tolerance, and increased basement membrane area with peripheral neuropathy.

Original languageEnglish
Pages (from-to)2615-2622
Number of pages8
JournalDiabetes
Volume52
Issue number10
DOIs
Publication statusPublished - 1 Oct 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Thrainsdottir, S., Malik, R., Dahlin, L. B., Wiksell, P., Eriksson, K. F., Rosén, I., Petersson, J., Greene, D. A., & Sundkvist, G. (2003). Endoneurial capillary abnormalities presage deterioration of glucose tolerance and accompany peripheral neuropathy in man. Diabetes, 52(10), 2615-2622. https://doi.org/10.2337/diabetes.52.10.2615