Endoneurial capillary abnormalities in mild human diabetic neuropathy

Rayaz Malik, A. Veves, E. A. Masson, A. K. Sharma, A. K. Ah-See, W. Schady, R. H. Lye, A. J M Boulton

Research output: Contribution to journalArticle

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Abstract

Microvascular factors have been implicated in the pathogenesis of human diabetic neuropathy. The extent of microangiopathy was assessed in 15 diabetic patients with clinically mild neuropathy and compared with eight age matched control subjects. Endoneurial capillary density was reduced (p < 0.04) and correlated significantly with reduced myelinated fibre density (p < 0.01). Both basement membrane area (p < 0.0001) and endothelial cell profile number per capillary (p < 0.002) were significantly increased in diabetic patients and correlated significantly with both neurophysiological and neuropathological measures of neuropathic severity. There was no evidence of endothelial cell hypertrophy as assessed by either cross sectional endothelial cell area or a reduction in luminal size. Furthermore, the percentage of closed vessels did not differ between diabetic patients and control subjects and failed to relate to measures of neuropathic severity. It was concluded that microvascular abnormalities are prominent in patients with clinically mild human diabetic neuropathy, and that these data provide further support for the role of endoneurial capillary disease in the development of this condition.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume55
Issue number7
Publication statusPublished - 1992
Externally publishedYes

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Diabetic Neuropathies
Endothelial Cells
Basement Membrane
Hypertrophy
Cell Count

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Malik, R., Veves, A., Masson, E. A., Sharma, A. K., Ah-See, A. K., Schady, W., ... Boulton, A. J. M. (1992). Endoneurial capillary abnormalities in mild human diabetic neuropathy. Journal of Neurology Neurosurgery and Psychiatry, 55(7), 557-561.

Endoneurial capillary abnormalities in mild human diabetic neuropathy. / Malik, Rayaz; Veves, A.; Masson, E. A.; Sharma, A. K.; Ah-See, A. K.; Schady, W.; Lye, R. H.; Boulton, A. J M.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 55, No. 7, 1992, p. 557-561.

Research output: Contribution to journalArticle

Malik, R, Veves, A, Masson, EA, Sharma, AK, Ah-See, AK, Schady, W, Lye, RH & Boulton, AJM 1992, 'Endoneurial capillary abnormalities in mild human diabetic neuropathy', Journal of Neurology Neurosurgery and Psychiatry, vol. 55, no. 7, pp. 557-561.
Malik R, Veves A, Masson EA, Sharma AK, Ah-See AK, Schady W et al. Endoneurial capillary abnormalities in mild human diabetic neuropathy. Journal of Neurology Neurosurgery and Psychiatry. 1992;55(7):557-561.
Malik, Rayaz ; Veves, A. ; Masson, E. A. ; Sharma, A. K. ; Ah-See, A. K. ; Schady, W. ; Lye, R. H. ; Boulton, A. J M. / Endoneurial capillary abnormalities in mild human diabetic neuropathy. In: Journal of Neurology Neurosurgery and Psychiatry. 1992 ; Vol. 55, No. 7. pp. 557-561.
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AU - Veves, A.

AU - Masson, E. A.

AU - Sharma, A. K.

AU - Ah-See, A. K.

AU - Schady, W.

AU - Lye, R. H.

AU - Boulton, A. J M

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AB - Microvascular factors have been implicated in the pathogenesis of human diabetic neuropathy. The extent of microangiopathy was assessed in 15 diabetic patients with clinically mild neuropathy and compared with eight age matched control subjects. Endoneurial capillary density was reduced (p < 0.04) and correlated significantly with reduced myelinated fibre density (p < 0.01). Both basement membrane area (p < 0.0001) and endothelial cell profile number per capillary (p < 0.002) were significantly increased in diabetic patients and correlated significantly with both neurophysiological and neuropathological measures of neuropathic severity. There was no evidence of endothelial cell hypertrophy as assessed by either cross sectional endothelial cell area or a reduction in luminal size. Furthermore, the percentage of closed vessels did not differ between diabetic patients and control subjects and failed to relate to measures of neuropathic severity. It was concluded that microvascular abnormalities are prominent in patients with clinically mild human diabetic neuropathy, and that these data provide further support for the role of endoneurial capillary disease in the development of this condition.

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