Endocytosis and presentation of liposome-associated antigens by B cells

Jean-Charles B. Grivel, K. Crook, L. Leserman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

B cells have limited endocytic capacity and are reported to endocytose and present liposome-encapsulated antigens poorly. B cells also endocytose soluble antigens poorly, except those for which their surface immunoglobulin is specific, which are taken up and presented efficiently. We present results indicating that, in vitro, B cells endocytose small liposomes bearing antigen with affinity for their surface immunoglobulin. Antigen encapsulated in liposomes targeted by antibody specific for surface immunoglobulin is presented to T cells as efficiently as specific antigen in soluble form. These studies provide a rational basis for the design of liposomes optimized to stimulate T-dependent B-cell responses.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalImmunoMethods
Volume4
Issue number3
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Endocytosis
Liposomes
B-Lymphocytes
B-Cell Antigen Receptors
Cells
Antigens
Bearings (structural)
T-cells
T-Lymphocytes
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Endocytosis and presentation of liposome-associated antigens by B cells. / Grivel, Jean-Charles B.; Crook, K.; Leserman, L.

In: ImmunoMethods, Vol. 4, No. 3, 1994, p. 223-228.

Research output: Contribution to journalArticle

Grivel, Jean-Charles B. ; Crook, K. ; Leserman, L. / Endocytosis and presentation of liposome-associated antigens by B cells. In: ImmunoMethods. 1994 ; Vol. 4, No. 3. pp. 223-228.
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