Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation

E. H. Dickerson, T. Sathyapalan, R. Knight, S. M. Maguiness, S. R. Killick, J. Robinson, Stephen Atkin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: There is increasing concern that environmental chemicals have a direct effect on fertility. Heavy metals such as mercury have been shown to affect various organ systems in humans including nervous system and skin, however they could also act as endocrine disrupting chemicals adversely affecting fertility. Metals such as zinc and selenium are essential micronutrients with diverse functions that may be important for reproductive outcomes. We measured mercury, zinc and selenium levels in the hair, a reliable reflection of long term environmental exposure and dietary status, to correlate with the outcome of ovarian hyperstimulation for in vitro fertilisation (IVF) treatment. Methods: We analysed the hair of 30 subfertile women for mercury, zinc and selenium using inductively coupled mass spectrometry. Each woman underwent one cycle of IVF treatment. Correlation between the levels of these trace metals and treatment outcomes was investigated. Results: Thirty women were recruited with mean (±SD) age of 32.7(4.4) years and BMI of 25.4(5.0)kg/m 2. Hair mercury concentration showed a negative correlation with oocyte yield (p∈<∈0.05,βcoefficient 0.38) and follicle number (p∈=∈0.03,β coefficient0.19) after ovarian stimulation. Zinc and selenium levels in hair correlated positively with oocyte yield after ovarian stimulation (p∈<∈0.05,β coefficient0.15) and (p∈=∈0.03,β coefficient0.21) respectively. Selenium levels in hair correlated significantly with follicle number following stimulation (p∈=∈0.04, βcoefficient0.22). There was no correlation between mercury, zinc and selenium in hair and their corresponding serum levels. Conclusion: These data suggest that mercury had a deleterious effect whilst there was a positive effect for zinc and selenium in the ovarian response to gonadotrophin therapy for IVF. Hair analysis offers a novel method of investigating the impact of long-term exposure to endocrine disruptors and nutritional status on reproductive outcomes.

Original languageEnglish
Pages (from-to)1223-1228
Number of pages6
JournalJournal of Assisted Reproduction and Genetics
Volume28
Issue number12
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

Fingerprint

Endocrine Disruptors
Selenium
Heavy Metals
Hair
Mercury
Zinc
Fertilization in Vitro
Ovulation Induction
Oocytes
Fertility
Metals
Micronutrients
Environmental Exposure
Nutritional Status
Gonadotropins
Nervous System
Mass Spectrometry
Therapeutics
Skin
Serum

Keywords

  • Endocrine disruptors
  • Heavy metals
  • IVF

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics(clinical)

Cite this

Dickerson, E. H., Sathyapalan, T., Knight, R., Maguiness, S. M., Killick, S. R., Robinson, J., & Atkin, S. (2011). Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation. Journal of Assisted Reproduction and Genetics, 28(12), 1223-1228. https://doi.org/10.1007/s10815-011-9652-3

Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation. / Dickerson, E. H.; Sathyapalan, T.; Knight, R.; Maguiness, S. M.; Killick, S. R.; Robinson, J.; Atkin, Stephen.

In: Journal of Assisted Reproduction and Genetics, Vol. 28, No. 12, 12.2011, p. 1223-1228.

Research output: Contribution to journalArticle

Dickerson, EH, Sathyapalan, T, Knight, R, Maguiness, SM, Killick, SR, Robinson, J & Atkin, S 2011, 'Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation', Journal of Assisted Reproduction and Genetics, vol. 28, no. 12, pp. 1223-1228. https://doi.org/10.1007/s10815-011-9652-3
Dickerson EH, Sathyapalan T, Knight R, Maguiness SM, Killick SR, Robinson J et al. Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation. Journal of Assisted Reproduction and Genetics. 2011 Dec;28(12):1223-1228. https://doi.org/10.1007/s10815-011-9652-3
Dickerson, E. H. ; Sathyapalan, T. ; Knight, R. ; Maguiness, S. M. ; Killick, S. R. ; Robinson, J. ; Atkin, Stephen. / Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation. In: Journal of Assisted Reproduction and Genetics. 2011 ; Vol. 28, No. 12. pp. 1223-1228.
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