Emerging roles of canonical TRP channels in neuronal function

Sunitha Bollimuntha, Senthil Selvaraj, Brij B. Singh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

28 Citations (Scopus)

Abstract

Ca 2+ signaling in neurons is intimately associated with the regulation of vital physiological processes including growth, survival and differentiation. In neurons, Ca 2+ elicits two major functions. First as a charge carrier, Ca 2+ reveals an indispensable role in information relay via membrane depolarization, exocytosis, and the release of neurotransmitters. Second on a global basis, Ca 2+ acts as a ubiquitous intracellular messenger to modulate neuronal function. Thus, to mediate Ca 2+-dependent physiological events, neurons engage multiple mode of Ca 2+ entry through a variety of Ca 2+ permeable plasma membrane channels. Here we discuss a subset of specialized Ca 2+-permeable non-selective TRPC channels and summarize their physiological and pathological role in the context of excitable cells. TRPC channels are predominately expressed in neuronal cells and are activated through complex mechanisms, including second messengers and store depletion. A growing body of evidence suggests a prime contribution of TRPC channels in regulating fundamental neuronal functions. TRPC channels have been shown to be associated with neuronal development, proliferation and differentiation. In addition, TRPC channels have also been suggested to have a potential role in regulating neurosecretion, long term potentiation, and synaptic plasticity. During the past years, numerous seminal discoveries relating TRPC channels to neurons have constantly emphasized on the significant contribution of this group of ion channels in regulating neuronal function. Here we review the major groundbreaking work that has uniquely placed TRPC channels in a pivotal position for governing neuronal Ca 2+ signaling and associated physiological responses.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages573-593
Number of pages21
Volume704
DOIs
Publication statusPublished - 15 Dec 2011
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume704
ISSN (Print)00652598

Fingerprint

Neurons
Ion Channels
Neurosecretion
Physiological Phenomena
Neuronal Plasticity
Long-Term Potentiation
Exocytosis
Depolarization
Second Messenger Systems
Cell membranes
Charge carriers
Plasticity
Neurotransmitter Agents
Cell Membrane
Membranes
Growth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Bollimuntha, S., Selvaraj, S., & Singh, B. B. (2011). Emerging roles of canonical TRP channels in neuronal function. In Advances in Experimental Medicine and Biology (Vol. 704, pp. 573-593). (Advances in Experimental Medicine and Biology; Vol. 704). https://doi.org/10.1007/978-94-007-0265-3_31

Emerging roles of canonical TRP channels in neuronal function. / Bollimuntha, Sunitha; Selvaraj, Senthil; Singh, Brij B.

Advances in Experimental Medicine and Biology. Vol. 704 2011. p. 573-593 (Advances in Experimental Medicine and Biology; Vol. 704).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bollimuntha, S, Selvaraj, S & Singh, BB 2011, Emerging roles of canonical TRP channels in neuronal function. in Advances in Experimental Medicine and Biology. vol. 704, Advances in Experimental Medicine and Biology, vol. 704, pp. 573-593. https://doi.org/10.1007/978-94-007-0265-3_31
Bollimuntha S, Selvaraj S, Singh BB. Emerging roles of canonical TRP channels in neuronal function. In Advances in Experimental Medicine and Biology. Vol. 704. 2011. p. 573-593. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-94-007-0265-3_31
Bollimuntha, Sunitha ; Selvaraj, Senthil ; Singh, Brij B. / Emerging roles of canonical TRP channels in neuronal function. Advances in Experimental Medicine and Biology. Vol. 704 2011. pp. 573-593 (Advances in Experimental Medicine and Biology).
@inproceedings{867ac60415154bdeb4619ff90f6b1d91,
title = "Emerging roles of canonical TRP channels in neuronal function",
abstract = "Ca 2+ signaling in neurons is intimately associated with the regulation of vital physiological processes including growth, survival and differentiation. In neurons, Ca 2+ elicits two major functions. First as a charge carrier, Ca 2+ reveals an indispensable role in information relay via membrane depolarization, exocytosis, and the release of neurotransmitters. Second on a global basis, Ca 2+ acts as a ubiquitous intracellular messenger to modulate neuronal function. Thus, to mediate Ca 2+-dependent physiological events, neurons engage multiple mode of Ca 2+ entry through a variety of Ca 2+ permeable plasma membrane channels. Here we discuss a subset of specialized Ca 2+-permeable non-selective TRPC channels and summarize their physiological and pathological role in the context of excitable cells. TRPC channels are predominately expressed in neuronal cells and are activated through complex mechanisms, including second messengers and store depletion. A growing body of evidence suggests a prime contribution of TRPC channels in regulating fundamental neuronal functions. TRPC channels have been shown to be associated with neuronal development, proliferation and differentiation. In addition, TRPC channels have also been suggested to have a potential role in regulating neurosecretion, long term potentiation, and synaptic plasticity. During the past years, numerous seminal discoveries relating TRPC channels to neurons have constantly emphasized on the significant contribution of this group of ion channels in regulating neuronal function. Here we review the major groundbreaking work that has uniquely placed TRPC channels in a pivotal position for governing neuronal Ca 2+ signaling and associated physiological responses.",
author = "Sunitha Bollimuntha and Senthil Selvaraj and Singh, {Brij B.}",
year = "2011",
month = "12",
day = "15",
doi = "10.1007/978-94-007-0265-3_31",
language = "English",
isbn = "9789400702646",
volume = "704",
series = "Advances in Experimental Medicine and Biology",
pages = "573--593",
booktitle = "Advances in Experimental Medicine and Biology",

}

TY - GEN

T1 - Emerging roles of canonical TRP channels in neuronal function

AU - Bollimuntha, Sunitha

AU - Selvaraj, Senthil

AU - Singh, Brij B.

PY - 2011/12/15

Y1 - 2011/12/15

N2 - Ca 2+ signaling in neurons is intimately associated with the regulation of vital physiological processes including growth, survival and differentiation. In neurons, Ca 2+ elicits two major functions. First as a charge carrier, Ca 2+ reveals an indispensable role in information relay via membrane depolarization, exocytosis, and the release of neurotransmitters. Second on a global basis, Ca 2+ acts as a ubiquitous intracellular messenger to modulate neuronal function. Thus, to mediate Ca 2+-dependent physiological events, neurons engage multiple mode of Ca 2+ entry through a variety of Ca 2+ permeable plasma membrane channels. Here we discuss a subset of specialized Ca 2+-permeable non-selective TRPC channels and summarize their physiological and pathological role in the context of excitable cells. TRPC channels are predominately expressed in neuronal cells and are activated through complex mechanisms, including second messengers and store depletion. A growing body of evidence suggests a prime contribution of TRPC channels in regulating fundamental neuronal functions. TRPC channels have been shown to be associated with neuronal development, proliferation and differentiation. In addition, TRPC channels have also been suggested to have a potential role in regulating neurosecretion, long term potentiation, and synaptic plasticity. During the past years, numerous seminal discoveries relating TRPC channels to neurons have constantly emphasized on the significant contribution of this group of ion channels in regulating neuronal function. Here we review the major groundbreaking work that has uniquely placed TRPC channels in a pivotal position for governing neuronal Ca 2+ signaling and associated physiological responses.

AB - Ca 2+ signaling in neurons is intimately associated with the regulation of vital physiological processes including growth, survival and differentiation. In neurons, Ca 2+ elicits two major functions. First as a charge carrier, Ca 2+ reveals an indispensable role in information relay via membrane depolarization, exocytosis, and the release of neurotransmitters. Second on a global basis, Ca 2+ acts as a ubiquitous intracellular messenger to modulate neuronal function. Thus, to mediate Ca 2+-dependent physiological events, neurons engage multiple mode of Ca 2+ entry through a variety of Ca 2+ permeable plasma membrane channels. Here we discuss a subset of specialized Ca 2+-permeable non-selective TRPC channels and summarize their physiological and pathological role in the context of excitable cells. TRPC channels are predominately expressed in neuronal cells and are activated through complex mechanisms, including second messengers and store depletion. A growing body of evidence suggests a prime contribution of TRPC channels in regulating fundamental neuronal functions. TRPC channels have been shown to be associated with neuronal development, proliferation and differentiation. In addition, TRPC channels have also been suggested to have a potential role in regulating neurosecretion, long term potentiation, and synaptic plasticity. During the past years, numerous seminal discoveries relating TRPC channels to neurons have constantly emphasized on the significant contribution of this group of ion channels in regulating neuronal function. Here we review the major groundbreaking work that has uniquely placed TRPC channels in a pivotal position for governing neuronal Ca 2+ signaling and associated physiological responses.

UR - http://www.scopus.com/inward/record.url?scp=79959772797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959772797&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-0265-3_31

DO - 10.1007/978-94-007-0265-3_31

M3 - Conference contribution

C2 - 21290317

AN - SCOPUS:79959772797

SN - 9789400702646

VL - 704

T3 - Advances in Experimental Medicine and Biology

SP - 573

EP - 593

BT - Advances in Experimental Medicine and Biology

ER -