Elevated blood neutrophil concentration in mania

Z. Kronfol, R. Turner, J. D. House, G. Winokur

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Total, differential, and absolute blood cell counts were compared in 66 untreated manics and 178 untreated schizophrenics. Mania was associated with significantly higher total leukocyte counts (p < .001), accounted for by a significant increase (p < .0001) in the number of neutrophils. There were no significant differences between the two groups in any other blood cell elements. Using normative values, manic patients had significantly higher frequencies of both leukocytosis (25.8% vs. 12.4%) and neutrophilia (34.8% vs. 12.4%) than the schizophrenic group. These data suggest a significant association between leukocytosis, neutrophilia, and mania.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalJournal of Clinical Psychiatry
Issue number2
Publication statusPublished - 1 Jan 1986


ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Kronfol, Z., Turner, R., House, J. D., & Winokur, G. (1986). Elevated blood neutrophil concentration in mania. Journal of Clinical Psychiatry, 47(2), 63-65.