Effects of short term metformin administration on androgens in diabetic men

Nadima S. Shegem, Abeer M. Alsheek Nasir, Anwar M. Batieha, Hatem El-Shanti, Kamel M. Ajlouni

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Abstract

Objective: Metformin, an oral hypoglycemic agent, has several other metabolic and hormonal effects. This study aims at identifying the metabolic effect of metformin on androgens in diabetic men. Methods: The study was conducted at The National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, Jordan from April 2001 to September 2001. We studied 15 men with type 2 diabetes mellitus by measuring fasting serum glucose, insulin, glycosylated hemoglobin, total and free testosterone, sex hormone binding globulin, dehydroepiandrosterone sulphate, 17-OH progesterone, luteinizing hormone, and follicle stimulating hormone before and after a short course of metformin. Results: There was a significant decrease in fasting serum glucose and glycosylated hemoglobin and increase in the level of 17-OH progesterone. The remainder of the measured parameters did not show any significant change. Although serum glucose and glycosylated hemoglobin decreased insulin levels were not changed. Conclusion: In contrast to normal men there was no change in androgen levels in diabetics but the 17-OH progesterone was elevated.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalSaudi Medical Journal
Volume25
Issue number1
Publication statusPublished - Jan 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Shegem, N. S., Alsheek Nasir, A. M., Batieha, A. M., El-Shanti, H., & Ajlouni, K. M. (2004). Effects of short term metformin administration on androgens in diabetic men. Saudi Medical Journal, 25(1), 75-78.