Effects of panretinal laser photocoagulation on the corneal nerve plexus and retinal nerve fiber layer in retinal vein occlusion

Gulfidan Bitirgen, Selman Belviranli, Rayaz Malik, Hurkan Kerimoglu, Ahmet Ozkagnici

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the effects of panretinal photocoagulation (PRP) on corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with unilateral central retinal vein occlusion (CRVO) who had previously undergone PRP treatment. Methods: Sixty-four eyes of 32 patients (19 male, 13 female) with unilateral ischemic type CRVO who had undergone PRP treatment at least 6 months previously were included in this cross-sectional study. The laser scanning in vivo corneal confocal microscope was used to determine corneal SBNP parameters. The peripapillary RNFL thickness was assessed with spectral-domain optical coherence tomography. Data obtained from the PRP-treated eyes were compared with those of the fellow unaffected eyes. Results: The mean age of patients was 63.5 ± 10.7 years (range 45-85 years). The mean nerve fiber density (NFD), nerve branch density, and nerve fiber length (NFL) were significantly lower in PRP-treated eyes compared with fellow eyes (p<0.001 for all). Average peripapillary RNFL thickness was significantly lower in PRP-treated eyes than in fellow eyes (p = 0.007). The NFD and NFL showed a modest but significant positive correlation with average peripapillary RNFL thickness (r = 0.310, p = 0.013 and r = 0.272, p = 0.030, respectively). conclusions: Significant reductions in corneal SBNP parameters and average peripapillary RNFL thickness were observed in the eyes of patients receiving PRP for the treatment of ischemic CRVO.

Original languageEnglish
Pages (from-to)591-595
Number of pages5
JournalEuropean Journal of Ophthalmology
Volume27
Issue number5
DOIs
Publication statusPublished - 1 Sep 2017

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Retinal Vein Occlusion
Light Coagulation
Nerve Fibers
Lasers
Retinal Vein
Optical Coherence Tomography
Therapeutics
Cross-Sectional Studies

Keywords

  • Cornea
  • In vivo confocal microscopy
  • Panretinal photocoagulation
  • Retinal nerve fiber layer
  • Sub-basal nerve plexus

ASJC Scopus subject areas

  • Medicine(all)
  • Ophthalmology

Cite this

Effects of panretinal laser photocoagulation on the corneal nerve plexus and retinal nerve fiber layer in retinal vein occlusion. / Bitirgen, Gulfidan; Belviranli, Selman; Malik, Rayaz; Kerimoglu, Hurkan; Ozkagnici, Ahmet.

In: European Journal of Ophthalmology, Vol. 27, No. 5, 01.09.2017, p. 591-595.

Research output: Contribution to journalArticle

Bitirgen, Gulfidan ; Belviranli, Selman ; Malik, Rayaz ; Kerimoglu, Hurkan ; Ozkagnici, Ahmet. / Effects of panretinal laser photocoagulation on the corneal nerve plexus and retinal nerve fiber layer in retinal vein occlusion. In: European Journal of Ophthalmology. 2017 ; Vol. 27, No. 5. pp. 591-595.
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