Effects of mechanosensitive ion channels on ventricular electrophysiology: Experimental and theoretical models

Peter Kohl, Christian Bollensdorff, Alan Garny

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in 'dynamo mode', the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechanosensitive ion channels, whose properties and pathophysiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electromechanical function.

Original languageEnglish
Pages (from-to)307-321
Number of pages15
JournalExperimental Physiology
Volume91
Issue number2
DOIs
Publication statusPublished - 1 Mar 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Physiology

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