Effects of (±)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats

K. Schirrmacher, D. Büsselberg, J. M. Langosch, J. Walden, U. Winter, D. Bingmann

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Kava pyrones extracted from pepper Piper methysticum are pharmacologically active compounds. Since kava pyrones exhibit anticonvulsive, analgesic and centrally muscle relaxing properties, the influence of a synthetic kava pyrone, (±)-kavain, on voltage-dependent ion channel currents was studied. Effects of (±)-kavain on voltage-activated inward currents were analysed in cultured dorsal root ganglion cells derived from neonatal rats. Voltage-activated Ca2+ and Na+ currents were elicited in the whole-cell configuration of the patch clamp technique. Extracellularly applied (±)-kavain dissolved in hydrous salt solutions reduced voltage-activated Ca2+ and Na+ channel currents within 3-5 min. As the solubility of (±)-kavain in hydrous solutions is low, dimethyl sulfoxide (DMSO) was added to the saline as a solvent for the drug in most experiments. When (±)-kavain was dissolved in DMSO, the drug induced a fast and pronounced reduction of both Ca2+ and Na+ currents, which partly recovered within 2-5 min even in the presence of the drug. The present study indicates that (±)-kavain reduces currents through voltage-activated Na+ and Ca2+ channels.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalEuropean Neuropsychopharmacology
Volume9
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 1999

Keywords

  • (±)-Kavain
  • Calcium channels
  • Na channels
  • Sensory spinal ganglion cells

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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