Effects of glycinergic inhibition failure on respiratory rhythm and pattern generation

Natalia A. Shevtsova, Dietrich Busselberg, Yaroslav I. Molkov, Anne M. Bischoff, Jeffrey C. Smith, Diethelm W. Richter, Ilya A. Rybak

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Inhibitory interactions between neurons of the respiratory network are involved in rhythm generation and pattern formation. Using a computational model of brainstem respiratory networks, we investigated the possible effects of suppressing glycinergic inhibition on the activity of different respiratory neuron types. Our study revealed that progressive suppression of glycinergic inhibition affected all neurons of the network and disturbed neural circuits involved in termination of inspiration. Causal was a dysfunction of postinspiratory inhibition targeting inspiratory neurons, which often led to irregular preterm reactivation of these neurons, producing double or multiple short-duration inspiratory bursts. An increasing blockade of glycinergic inhibition led to apneustic inspiratory activity. Similar disturbances of glycinergic inhibition also occur during hypoxia. A clear difference in prolonged hypoxia, however, is that the rhythm terminates in expiratory apnea. The critical function of glycinergic inhibition for normal respiratory rhythm generation and the consequences of its reduction, including in pathological conditions, are discussed.

Original languageEnglish
Pages (from-to)25-38
Number of pages14
JournalProgress in Brain Research
Volume209
DOIs
Publication statusPublished - 2014

Fingerprint

Respiratory Insufficiency
Neurons
Apnea
Brain Stem
Hypoxia

Keywords

  • Apnea
  • Apneusis
  • Computational modeling
  • Glycinergic inhibition
  • Hypoxia
  • Pre-Bötzinger complex
  • Respiratory rhythm
  • Translational medicine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Shevtsova, N. A., Busselberg, D., Molkov, Y. I., Bischoff, A. M., Smith, J. C., Richter, D. W., & Rybak, I. A. (2014). Effects of glycinergic inhibition failure on respiratory rhythm and pattern generation. Progress in Brain Research, 209, 25-38. https://doi.org/10.1016/B978-0-444-63274-6.00002-3

Effects of glycinergic inhibition failure on respiratory rhythm and pattern generation. / Shevtsova, Natalia A.; Busselberg, Dietrich; Molkov, Yaroslav I.; Bischoff, Anne M.; Smith, Jeffrey C.; Richter, Diethelm W.; Rybak, Ilya A.

In: Progress in Brain Research, Vol. 209, 2014, p. 25-38.

Research output: Contribution to journalArticle

Shevtsova, Natalia A. ; Busselberg, Dietrich ; Molkov, Yaroslav I. ; Bischoff, Anne M. ; Smith, Jeffrey C. ; Richter, Diethelm W. ; Rybak, Ilya A. / Effects of glycinergic inhibition failure on respiratory rhythm and pattern generation. In: Progress in Brain Research. 2014 ; Vol. 209. pp. 25-38.
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