Effects of curcumin on hypoxia-inducible factor as a new therapeutic target

Afsane Bahrami, Stephen Atkin, Muhammed Majeed, Amirhossein Sahebkar

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that consists of two subunits, the HIF-1α and HIF-1β (ARNT). Under hypoxic conditions, HIF-1 is an adaptive system that regulates the transcription of multiple genes associated with growth, angiogenesis, proliferation, glucose transport, metabolism, pH regulation and cell death. However, aberrant HIF-1 activation contributes to the pathophysiology of several human diseases such as cancer, ischemic cardiovascular disorders, and pulmonary and kidney diseases. A growing body of evidence indicates that curcumin, a natural bioactive compound of turmeric root, significantly targets both HIF-1 subunits, but is more potent against HIF-1α. In this review, we have summarized the knowledge about the pharmacological effects of curcumin on HIF-1 and the related molecular mechanisms that may be effective candidates for the development of multi-targeted therapy for several human diseases.

Original languageEnglish
Pages (from-to)159-169
Number of pages11
JournalPharmacological Research
Volume137
DOIs
Publication statusPublished - 1 Nov 2018

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Keywords

  • Aryl hydrocarbon receptor nuclear translocator
  • Hypoxia-responsive elements
  • Turmeric
  • Von Hippel-Lindau

ASJC Scopus subject areas

  • Pharmacology

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