Effects of acute or chronic administration of novel 3, 4-dimethoxyphenylethylamine derivates on anxiety-like behavior

Julia Fedotova, Victoria Barishpolec, Anthony Zulli, Dietrich Busselberg, Ludovit Gaspar, Peter Kruzliak

Research output: Contribution to journalArticle

Abstract

Novel anxiolytic medications are necessary to broaden treatment therapy. Thus, the aim of the present study was to compare the clinically effective anxiolytic, diazepam with the novel 3, 4-dimethoxyphenylethylamine derivates. The novel 3, 4-dimethoxyphenylethylamine derivates (PK, 0.1, 1.0, 10.0 mg/kg, i.p.) and diazepam (1.0 mg/kg) were injected acutely or chronically in animals subjected to the black-white model and the open field test. The acute administration of PK-2122 (0.1 mg/kg, i.p.) exerted anxiogenic-like effect, while in the middle or high doses PK-2122 exerted anxiolytic-like effect compared with the control group (p<0.05). The repeated treatment with PK-2111 was followed by anxiolytic-like effect in doses of 0.1 or 1.0 mg/kg which was more significant compared not only with control group, but with comparison to group treated with diazepam (p<0.05). Chronic treatment with PK-2123 or PK-2122 in all tested doses produced anxiolytic-like effect (p<0.05), compared with control group and diazepam group. These results demonstrate that PK-2126, but not PK-2122, is dose independent and may be effective in experimental model of anxiety in rats when administered acutely or repeatedly.

Original languageEnglish
Pages (from-to)2462-2473
Number of pages12
JournalAmerican Journal of Translational Research
Volume7
Issue number11
Publication statusPublished - 2015

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Keywords

  • Anxiety
  • Black and white model
  • Dopamine
  • Open field test

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Clinical Biochemistry
  • Molecular Medicine

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