Effector lymphoid tissue and its crucial role in protective immunity

Nicholas J. Van Panhuys, Rachel Perret, Melanie Prout, Franca Ronchese, Graham Le Gros

Research output: Contribution to journalReview article

30 Citations (Scopus)


It is often argued that T cell-mediated immunity to secondary infection is dependent on the 'accelerated' responses of memory T cells in lymph nodes. However, new evidence points to a crucial role for effector memory T cells, which are resident in peripheral tissues, in immune protection. These T cells, which reside in peripheral tissues, are not necessarily bound by an anatomical structure and can be present at many sites. Collectively, they represent a third functional tissue of the immune system, uniquely specialized to mediate protective immunity. We propose that the paradigm 'effector lymphoid tissue' needs to be articulated and developed as a focus of new research to describe and understand the unique role this tissue has in protective immunity.

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalTrends in Immunology
Issue number5
Publication statusPublished - May 2005
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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