Effector lymphoid tissue and its crucial role in protective immunity

Nicholas J. Van Panhuys, Rachel Perret, Melanie Prout, Franca Ronchese, Graham Le Gros

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

It is often argued that T cell-mediated immunity to secondary infection is dependent on the 'accelerated' responses of memory T cells in lymph nodes. However, new evidence points to a crucial role for effector memory T cells, which are resident in peripheral tissues, in immune protection. These T cells, which reside in peripheral tissues, are not necessarily bound by an anatomical structure and can be present at many sites. Collectively, they represent a third functional tissue of the immune system, uniquely specialized to mediate protective immunity. We propose that the paradigm 'effector lymphoid tissue' needs to be articulated and developed as a focus of new research to describe and understand the unique role this tissue has in protective immunity.

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalTrends in Immunology
Volume26
Issue number5
DOIs
Publication statusPublished - May 2005
Externally publishedYes

Fingerprint

Lymphoid Tissue
Immunity
T-Lymphocytes
Coinfection
Cellular Immunity
Immune System
Lymph Nodes
Research

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Effector lymphoid tissue and its crucial role in protective immunity. / Van Panhuys, Nicholas J.; Perret, Rachel; Prout, Melanie; Ronchese, Franca; Le Gros, Graham.

In: Trends in Immunology, Vol. 26, No. 5, 05.2005, p. 242-247.

Research output: Contribution to journalReview article

Van Panhuys, Nicholas J. ; Perret, Rachel ; Prout, Melanie ; Ronchese, Franca ; Le Gros, Graham. / Effector lymphoid tissue and its crucial role in protective immunity. In: Trends in Immunology. 2005 ; Vol. 26, No. 5. pp. 242-247.
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