Effect of Roux-en-Y bariatric surgery on lipoproteins, insulin resistance, and systemic and vascular inflammation in obesity and diabetes

Rahul Yadav, Salam Hama, Yifen Liu, Tarza Siahmansur, Jonathan Schofield, Akheel A. Syed, Michael France, Philip Pemberton, Safwaan Adam, Jan Hoong Ho, Reza Aghamohammadzadeh, Shaishav Dhage, Rachelle Donn, Rayaz Malik, John P. New, Maria Jeziorska, Paul Durrington, Basil A. Ammori, Handrean Soran

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective: To evaluate changes in lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction following Roux-en-Y bariatric surgery in obese patients with and without diabetes. Materials and methods: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction were measured in 37 obese patients with (n = 17) and without (n = 20) T2DM, before and 6 and 12 months after Roux-en-Y bariatric surgery. Two way between subject ANOVA was carried out to study the interaction between independent variables (time since surgery and presence of diabetes) and all dependent variables. Results: There was a significant effect of time since surgery on (large effect size) weight, body mass index (BMI), waist circumference, triglycerides (TG), small-dense LDL apolipoprotein B (sdLDL ApoB), HOMA-IR, CRP, MCP-1, ICAM-1, E-selectin, P-selectin, leptin, and adiponectin. BMI and waist circumference had the largest impact of time since surgery. The effect of time since surgery was noticed mostly in the first 6 months. Absence of diabetes led to a significantly greater reduction in total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol although the effect size was small to medium. There was a greater reduction in TG and HOMA-IR in patients with diabetes with a small effect size. No patients were lost to follow up. Conclusion: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction improve mostly 6 months after bariatric surgery in obese patients with and without diabetes.

Original languageEnglish
Article number1512
JournalFrontiers in Immunology
Volume8
Issue numberNOV
DOIs
Publication statusPublished - 15 Nov 2017

Fingerprint

Bariatric Surgery
Lipoproteins
Blood Vessels
Insulin Resistance
Obesity
Inflammation
Apolipoproteins B
Waist Circumference
Triglycerides
Body Mass Index
P-Selectin
E-Selectin
Lost to Follow-Up
Adiponectin
Intercellular Adhesion Molecule-1
Leptin
LDL Cholesterol
Type 2 Diabetes Mellitus
Weight Loss
Analysis of Variance

Keywords

  • Diabetes
  • Insulin resistance
  • Lipoproteins
  • Roux-en-Y
  • Vascular inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Effect of Roux-en-Y bariatric surgery on lipoproteins, insulin resistance, and systemic and vascular inflammation in obesity and diabetes. / Yadav, Rahul; Hama, Salam; Liu, Yifen; Siahmansur, Tarza; Schofield, Jonathan; Syed, Akheel A.; France, Michael; Pemberton, Philip; Adam, Safwaan; Ho, Jan Hoong; Aghamohammadzadeh, Reza; Dhage, Shaishav; Donn, Rachelle; Malik, Rayaz; New, John P.; Jeziorska, Maria; Durrington, Paul; Ammori, Basil A.; Soran, Handrean.

In: Frontiers in Immunology, Vol. 8, No. NOV, 1512, 15.11.2017.

Research output: Contribution to journalArticle

Yadav, R, Hama, S, Liu, Y, Siahmansur, T, Schofield, J, Syed, AA, France, M, Pemberton, P, Adam, S, Ho, JH, Aghamohammadzadeh, R, Dhage, S, Donn, R, Malik, R, New, JP, Jeziorska, M, Durrington, P, Ammori, BA & Soran, H 2017, 'Effect of Roux-en-Y bariatric surgery on lipoproteins, insulin resistance, and systemic and vascular inflammation in obesity and diabetes', Frontiers in Immunology, vol. 8, no. NOV, 1512. https://doi.org/10.3389/fimmu.2017.01512
Yadav, Rahul ; Hama, Salam ; Liu, Yifen ; Siahmansur, Tarza ; Schofield, Jonathan ; Syed, Akheel A. ; France, Michael ; Pemberton, Philip ; Adam, Safwaan ; Ho, Jan Hoong ; Aghamohammadzadeh, Reza ; Dhage, Shaishav ; Donn, Rachelle ; Malik, Rayaz ; New, John P. ; Jeziorska, Maria ; Durrington, Paul ; Ammori, Basil A. ; Soran, Handrean. / Effect of Roux-en-Y bariatric surgery on lipoproteins, insulin resistance, and systemic and vascular inflammation in obesity and diabetes. In: Frontiers in Immunology. 2017 ; Vol. 8, No. NOV.
@article{a120474f677b43eeb3f91fb4f789b657,
title = "Effect of Roux-en-Y bariatric surgery on lipoproteins, insulin resistance, and systemic and vascular inflammation in obesity and diabetes",
abstract = "Purpose: Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective: To evaluate changes in lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction following Roux-en-Y bariatric surgery in obese patients with and without diabetes. Materials and methods: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction were measured in 37 obese patients with (n = 17) and without (n = 20) T2DM, before and 6 and 12 months after Roux-en-Y bariatric surgery. Two way between subject ANOVA was carried out to study the interaction between independent variables (time since surgery and presence of diabetes) and all dependent variables. Results: There was a significant effect of time since surgery on (large effect size) weight, body mass index (BMI), waist circumference, triglycerides (TG), small-dense LDL apolipoprotein B (sdLDL ApoB), HOMA-IR, CRP, MCP-1, ICAM-1, E-selectin, P-selectin, leptin, and adiponectin. BMI and waist circumference had the largest impact of time since surgery. The effect of time since surgery was noticed mostly in the first 6 months. Absence of diabetes led to a significantly greater reduction in total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol although the effect size was small to medium. There was a greater reduction in TG and HOMA-IR in patients with diabetes with a small effect size. No patients were lost to follow up. Conclusion: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction improve mostly 6 months after bariatric surgery in obese patients with and without diabetes.",
keywords = "Diabetes, Insulin resistance, Lipoproteins, Roux-en-Y, Vascular inflammation",
author = "Rahul Yadav and Salam Hama and Yifen Liu and Tarza Siahmansur and Jonathan Schofield and Syed, {Akheel A.} and Michael France and Philip Pemberton and Safwaan Adam and Ho, {Jan Hoong} and Reza Aghamohammadzadeh and Shaishav Dhage and Rachelle Donn and Rayaz Malik and New, {John P.} and Maria Jeziorska and Paul Durrington and Ammori, {Basil A.} and Handrean Soran",
year = "2017",
month = "11",
day = "15",
doi = "10.3389/fimmu.2017.01512",
language = "English",
volume = "8",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
number = "NOV",

}

TY - JOUR

T1 - Effect of Roux-en-Y bariatric surgery on lipoproteins, insulin resistance, and systemic and vascular inflammation in obesity and diabetes

AU - Yadav, Rahul

AU - Hama, Salam

AU - Liu, Yifen

AU - Siahmansur, Tarza

AU - Schofield, Jonathan

AU - Syed, Akheel A.

AU - France, Michael

AU - Pemberton, Philip

AU - Adam, Safwaan

AU - Ho, Jan Hoong

AU - Aghamohammadzadeh, Reza

AU - Dhage, Shaishav

AU - Donn, Rachelle

AU - Malik, Rayaz

AU - New, John P.

AU - Jeziorska, Maria

AU - Durrington, Paul

AU - Ammori, Basil A.

AU - Soran, Handrean

PY - 2017/11/15

Y1 - 2017/11/15

N2 - Purpose: Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective: To evaluate changes in lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction following Roux-en-Y bariatric surgery in obese patients with and without diabetes. Materials and methods: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction were measured in 37 obese patients with (n = 17) and without (n = 20) T2DM, before and 6 and 12 months after Roux-en-Y bariatric surgery. Two way between subject ANOVA was carried out to study the interaction between independent variables (time since surgery and presence of diabetes) and all dependent variables. Results: There was a significant effect of time since surgery on (large effect size) weight, body mass index (BMI), waist circumference, triglycerides (TG), small-dense LDL apolipoprotein B (sdLDL ApoB), HOMA-IR, CRP, MCP-1, ICAM-1, E-selectin, P-selectin, leptin, and adiponectin. BMI and waist circumference had the largest impact of time since surgery. The effect of time since surgery was noticed mostly in the first 6 months. Absence of diabetes led to a significantly greater reduction in total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol although the effect size was small to medium. There was a greater reduction in TG and HOMA-IR in patients with diabetes with a small effect size. No patients were lost to follow up. Conclusion: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction improve mostly 6 months after bariatric surgery in obese patients with and without diabetes.

AB - Purpose: Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective: To evaluate changes in lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction following Roux-en-Y bariatric surgery in obese patients with and without diabetes. Materials and methods: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction were measured in 37 obese patients with (n = 17) and without (n = 20) T2DM, before and 6 and 12 months after Roux-en-Y bariatric surgery. Two way between subject ANOVA was carried out to study the interaction between independent variables (time since surgery and presence of diabetes) and all dependent variables. Results: There was a significant effect of time since surgery on (large effect size) weight, body mass index (BMI), waist circumference, triglycerides (TG), small-dense LDL apolipoprotein B (sdLDL ApoB), HOMA-IR, CRP, MCP-1, ICAM-1, E-selectin, P-selectin, leptin, and adiponectin. BMI and waist circumference had the largest impact of time since surgery. The effect of time since surgery was noticed mostly in the first 6 months. Absence of diabetes led to a significantly greater reduction in total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol although the effect size was small to medium. There was a greater reduction in TG and HOMA-IR in patients with diabetes with a small effect size. No patients were lost to follow up. Conclusion: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction improve mostly 6 months after bariatric surgery in obese patients with and without diabetes.

KW - Diabetes

KW - Insulin resistance

KW - Lipoproteins

KW - Roux-en-Y

KW - Vascular inflammation

UR - http://www.scopus.com/inward/record.url?scp=85034026945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034026945&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2017.01512

DO - 10.3389/fimmu.2017.01512

M3 - Article

VL - 8

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - NOV

M1 - 1512

ER -