Effect of metformin on plasma fibrinogen concentrations: A systematic review and meta-analysis of randomized placebo-controlled trials

Luis E. Simental-Mendía, Matteo Pirro, Stephen Atkin, Maciej Banach, Dimitri P. Mikhailidis, Amirhossein Sahebkar

Research output: Contribution to journalReview article


Objective: Fibrinogen is a key mediator of thrombosis and it has been implicated in the pathogenesis of atherosclerosis. Because metformin has shown a potential protective effect on different atherothrombotic risk factors, we assessed in this meta-analysis its effect on plasma fibrinogen concentrations. Methods: A systematic review and meta-analysis was carried out to identify randomized placebo-controlled trials evaluating the effect of metformin administration on fibrinogen levels. The search included PubMed-Medline, Scopus, ISI Web of Knowledge and Google Scholar databases (by June 2, 2017) and quality of studies was performed according to Cochrane criteria. Quantitative data synthesis was conducted using a random-effects model and sensitivity analysis by the leave-one-out method. Meta-regression analysis was performed to assess the modifiers of treatment response. Results: Meta-analysis of data from 9 randomized placebo-controlled clinical trials with 2302 patients comprising 10 treatment arms did not suggest a significant change in plasma fibrinogen concentrations following metformin therapy (WMD:-0.25 g/L, 95% CI:-0.53, 0.04, p = 0.092). The effect size was robust in the leave-one-out sensitivity analysis and remained non-significant after omission of each single study from the meta-analysis. Conclusion: No significant effect of metformin on plasma fibrinogen concentrations was demonstrated in the current meta-analysis.

Original languageEnglish
Pages (from-to)1034-1040
Number of pages7
JournalCurrent Pharmaceutical Design
Issue number9
Publication statusPublished - 1 Jan 2018



  • Coagulation
  • Fibrinogen
  • Hemostasis
  • Meta-analysis
  • Metformin
  • Thrombosis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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