Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis

Z. Borok, R. Buhl, R. C. Hubbard, K. J. Holroyd, J. H. Roum, D. B. Czerski, Ronald Crystal, G. J. Grimes, A. D. Bokser, A. M. Cantin

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients with IPF. Total ELF glutathione rose transiently, ELF oxidised glutathione concentrations increased, and there was a decrease in spontaneous superoxide anion release by alveolar macrophages. Thus, glutathione by aerosol could be a means of reversing the oxidant-antioxidant imbalance in IPF.

Original languageEnglish
Pages (from-to)215-216
Number of pages2
JournalThe Lancet
Volume338
Issue number8761
DOIs
Publication statusPublished - 27 Jul 1991
Externally publishedYes

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Idiopathic Pulmonary Fibrosis
Aerosols
Oxidants
Glutathione
Antioxidants
Glutathione Disulfide
Alveolar Macrophages
Superoxides
Inflammation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Borok, Z., Buhl, R., Hubbard, R. C., Holroyd, K. J., Roum, J. H., Czerski, D. B., ... Cantin, A. M. (1991). Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. The Lancet, 338(8761), 215-216. https://doi.org/10.1016/0140-6736(91)90350-X

Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. / Borok, Z.; Buhl, R.; Hubbard, R. C.; Holroyd, K. J.; Roum, J. H.; Czerski, D. B.; Crystal, Ronald; Grimes, G. J.; Bokser, A. D.; Cantin, A. M.

In: The Lancet, Vol. 338, No. 8761, 27.07.1991, p. 215-216.

Research output: Contribution to journalArticle

Borok, Z, Buhl, R, Hubbard, RC, Holroyd, KJ, Roum, JH, Czerski, DB, Crystal, R, Grimes, GJ, Bokser, AD & Cantin, AM 1991, 'Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis', The Lancet, vol. 338, no. 8761, pp. 215-216. https://doi.org/10.1016/0140-6736(91)90350-X
Borok Z, Buhl R, Hubbard RC, Holroyd KJ, Roum JH, Czerski DB et al. Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. The Lancet. 1991 Jul 27;338(8761):215-216. https://doi.org/10.1016/0140-6736(91)90350-X
Borok, Z. ; Buhl, R. ; Hubbard, R. C. ; Holroyd, K. J. ; Roum, J. H. ; Czerski, D. B. ; Crystal, Ronald ; Grimes, G. J. ; Bokser, A. D. ; Cantin, A. M. / Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. In: The Lancet. 1991 ; Vol. 338, No. 8761. pp. 215-216.
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