DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases

Abdelkrim Khadir, Sina Kavalakatt, Mohammed Dehbi, Monira Alarouj, Abdullah Bennakhi, Ali Tiss, Naser Elkum

Research output: Contribution to journalArticle

Abstract

Background. Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory markers with CVD recurrent events. Here, we explored this potential link by assessing plasma dual-specificity phosphatase 1 (DUSP1) levels and comparing them to high-sensitivity CRP (hsCRP) and oxidized low-density lipoprotein (oxLDL) levels and their associations to conventional CVD risk factors in confirmed CVD patients. Methods. Human adults with reported CVD (n=207) and controls (n=70) living in Kuwait were used in this study. Anthropometric and classical biochemical parameters were determined. Plasma levels of DUSP1, oxLDL, and hsCRP were measured using human enzyme-linked immunosorbent assay kits. Results. DUSP1 and hsCRP plasma levels and their least square means were higher in CVD cases, while oxLDL plasma levels were lower (p<0.05). Multivariate logistic regression analysis showed that DUSP1 and hsCRP are independently associated with CVD in the studied population, as reflected by 2-fold and 1.5-fold increased risks with increased levels of DUSP1 and hsCRP, respectively. In our study, DUSP1 levels were found to be associated with CVD despite statin treatment and diabetes status (p<0.05), whereas hsCRP mainly correlated with obesity markers. Conclusions. Circulating DUSP1 might be a predictor of chronic subclinical inflammation and residual risk in CVD patients, whereas our data suggest that the association between hsCRP and CVD is largely accounted for adiposity risk factors.

Original languageEnglish
Article number9529621
JournalDisease Markers
Volume2018
DOIs
Publication statusPublished - 1 Jan 2018

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Dual Specificity Phosphatase 1
Cardiovascular Diseases
Inflammation
Plasmas
Kuwait
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Immunosorbents
Adiposity
Medical problems
Least-Squares Analysis
Regression analysis
Logistics
Epidemiologic Studies
Assays
Obesity
Logistic Models
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

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DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases. / Khadir, Abdelkrim; Kavalakatt, Sina; Dehbi, Mohammed; Alarouj, Monira; Bennakhi, Abdullah; Tiss, Ali; Elkum, Naser.

In: Disease Markers, Vol. 2018, 9529621, 01.01.2018.

Research output: Contribution to journalArticle

Khadir, Abdelkrim ; Kavalakatt, Sina ; Dehbi, Mohammed ; Alarouj, Monira ; Bennakhi, Abdullah ; Tiss, Ali ; Elkum, Naser. / DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases. In: Disease Markers. 2018 ; Vol. 2018.
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