Dual infection with HIV and malaria fuels the spread of both diseases in Sub-Saharan Africa

Laith Aburaddad, Padmaja Patnaik, James G. Kublin

Research output: Contribution to journalArticle

300 Citations (Scopus)

Abstract

Mounting evidence has revealed pathological interactions between HIV and malaria in dually infected patients, but the public health implications of the interplay have remained unclear. A transient almost one-log elevation in HIV viral load occurs during febrile malaria episodes; in addition, susceptibility to malaria is enhanced in HIV-infected patients. A mathematical model applied to a setting in Kenya with an adult population of roughly 200,000 estimated that, since 1980, the disease interaction may have been responsible for 8,500 excess HIV infections and 980,000 excess malaria episodes. Co-infection might also have facilitated the geographic expansion of malaria in areas where HIV prevalence is high. Hence, transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa.

Original languageEnglish
Pages (from-to)1603-1606
Number of pages4
JournalScience
Volume314
Issue number5805
DOIs
Publication statusPublished - 8 Dec 2006
Externally publishedYes

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Africa South of the Sahara
Malaria
HIV Infections
HIV
Viral Load
Coinfection
Kenya
Fever
Theoretical Models
Public Health
Population

ASJC Scopus subject areas

  • General

Cite this

Dual infection with HIV and malaria fuels the spread of both diseases in Sub-Saharan Africa. / Aburaddad, Laith; Patnaik, Padmaja; Kublin, James G.

In: Science, Vol. 314, No. 5805, 08.12.2006, p. 1603-1606.

Research output: Contribution to journalArticle

Aburaddad, Laith ; Patnaik, Padmaja ; Kublin, James G. / Dual infection with HIV and malaria fuels the spread of both diseases in Sub-Saharan Africa. In: Science. 2006 ; Vol. 314, No. 5805. pp. 1603-1606.
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