Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis

C. Casas, S. Martínez, M. A. Pritchard, J. J. Fuentes, M. Nadal, J. Guimerà, M. Arbonés, J. Flórez, E. Soriano, Xavier P. Estivill, S. Alcántara

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We have demonstrated that DSCR1 acts as a negative regulator of calcineurin-mediated signaling and that its transcript is overexpressed in the Down syndrome (DS) fetal brain. To evaluate the possible involvement of DSCR1 in DS, we have cloned the mouse gene and analyzed its expression pattern in the central nervous system (CNS). Early expression of Dscr1 is detected mainly in the heart tube and in the CNS in rhombomere 4 and the pretectum. From embryonic day 14.5 onwards, Dscr1 is widely distributed in the CNS but becomes more restricted as the brain matures. We confirmed its neuronal expression pattern in the adult, preferentially in Purkinje and pyramidal cells, by double labeling with glial fibrillary acidic protein. We also show that although Dscr1 is present in trisomy in the Ts65Dn mouse, the adult brain expression pattern is not significantly altered. This expression pattern indicated that Dscr1 is a developmentally regulated gene involved in neurogenesis and cardiogenesis and suggests that it may contribute to the alterations observed in these organ systems in DS patients.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalMechanisms of Development
Volume101
Issue number1-2
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Neurogenesis
Down Syndrome
Heart Ventricles
Central Nervous System
Brain
Pyramidal Cells
Calcineurin
Purkinje Cells
Glial Fibrillary Acidic Protein
Trisomy
Genes
Calcineurin Inhibitors

Keywords

  • Calcineurin
  • Chromosome 21
  • Down syndrome
  • Dscr1
  • Heart
  • Nervous system
  • Nuclear factor of activated T cells
  • Rhombomere
  • Ts65Dn mouse

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis. / Casas, C.; Martínez, S.; Pritchard, M. A.; Fuentes, J. J.; Nadal, M.; Guimerà, J.; Arbonés, M.; Flórez, J.; Soriano, E.; Estivill, Xavier P.; Alcántara, S.

In: Mechanisms of Development, Vol. 101, No. 1-2, 2001, p. 289-292.

Research output: Contribution to journalArticle

Casas, C, Martínez, S, Pritchard, MA, Fuentes, JJ, Nadal, M, Guimerà, J, Arbonés, M, Flórez, J, Soriano, E, Estivill, XP & Alcántara, S 2001, 'Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis', Mechanisms of Development, vol. 101, no. 1-2, pp. 289-292. https://doi.org/10.1016/S0925-4773(00)00583-9
Casas, C. ; Martínez, S. ; Pritchard, M. A. ; Fuentes, J. J. ; Nadal, M. ; Guimerà, J. ; Arbonés, M. ; Flórez, J. ; Soriano, E. ; Estivill, Xavier P. ; Alcántara, S. / Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis. In: Mechanisms of Development. 2001 ; Vol. 101, No. 1-2. pp. 289-292.
@article{f5fa92f161ce42dcb1361a8737143dfe,
title = "Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis",
abstract = "We have demonstrated that DSCR1 acts as a negative regulator of calcineurin-mediated signaling and that its transcript is overexpressed in the Down syndrome (DS) fetal brain. To evaluate the possible involvement of DSCR1 in DS, we have cloned the mouse gene and analyzed its expression pattern in the central nervous system (CNS). Early expression of Dscr1 is detected mainly in the heart tube and in the CNS in rhombomere 4 and the pretectum. From embryonic day 14.5 onwards, Dscr1 is widely distributed in the CNS but becomes more restricted as the brain matures. We confirmed its neuronal expression pattern in the adult, preferentially in Purkinje and pyramidal cells, by double labeling with glial fibrillary acidic protein. We also show that although Dscr1 is present in trisomy in the Ts65Dn mouse, the adult brain expression pattern is not significantly altered. This expression pattern indicated that Dscr1 is a developmentally regulated gene involved in neurogenesis and cardiogenesis and suggests that it may contribute to the alterations observed in these organ systems in DS patients.",
keywords = "Calcineurin, Chromosome 21, Down syndrome, Dscr1, Heart, Nervous system, Nuclear factor of activated T cells, Rhombomere, Ts65Dn mouse",
author = "C. Casas and S. Mart{\'i}nez and Pritchard, {M. A.} and Fuentes, {J. J.} and M. Nadal and J. Guimer{\`a} and M. Arbon{\'e}s and J. Fl{\'o}rez and E. Soriano and Estivill, {Xavier P.} and S. Alc{\'a}ntara",
year = "2001",
doi = "10.1016/S0925-4773(00)00583-9",
language = "English",
volume = "101",
pages = "289--292",
journal = "Mechanisms of Development",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis

AU - Casas, C.

AU - Martínez, S.

AU - Pritchard, M. A.

AU - Fuentes, J. J.

AU - Nadal, M.

AU - Guimerà, J.

AU - Arbonés, M.

AU - Flórez, J.

AU - Soriano, E.

AU - Estivill, Xavier P.

AU - Alcántara, S.

PY - 2001

Y1 - 2001

N2 - We have demonstrated that DSCR1 acts as a negative regulator of calcineurin-mediated signaling and that its transcript is overexpressed in the Down syndrome (DS) fetal brain. To evaluate the possible involvement of DSCR1 in DS, we have cloned the mouse gene and analyzed its expression pattern in the central nervous system (CNS). Early expression of Dscr1 is detected mainly in the heart tube and in the CNS in rhombomere 4 and the pretectum. From embryonic day 14.5 onwards, Dscr1 is widely distributed in the CNS but becomes more restricted as the brain matures. We confirmed its neuronal expression pattern in the adult, preferentially in Purkinje and pyramidal cells, by double labeling with glial fibrillary acidic protein. We also show that although Dscr1 is present in trisomy in the Ts65Dn mouse, the adult brain expression pattern is not significantly altered. This expression pattern indicated that Dscr1 is a developmentally regulated gene involved in neurogenesis and cardiogenesis and suggests that it may contribute to the alterations observed in these organ systems in DS patients.

AB - We have demonstrated that DSCR1 acts as a negative regulator of calcineurin-mediated signaling and that its transcript is overexpressed in the Down syndrome (DS) fetal brain. To evaluate the possible involvement of DSCR1 in DS, we have cloned the mouse gene and analyzed its expression pattern in the central nervous system (CNS). Early expression of Dscr1 is detected mainly in the heart tube and in the CNS in rhombomere 4 and the pretectum. From embryonic day 14.5 onwards, Dscr1 is widely distributed in the CNS but becomes more restricted as the brain matures. We confirmed its neuronal expression pattern in the adult, preferentially in Purkinje and pyramidal cells, by double labeling with glial fibrillary acidic protein. We also show that although Dscr1 is present in trisomy in the Ts65Dn mouse, the adult brain expression pattern is not significantly altered. This expression pattern indicated that Dscr1 is a developmentally regulated gene involved in neurogenesis and cardiogenesis and suggests that it may contribute to the alterations observed in these organ systems in DS patients.

KW - Calcineurin

KW - Chromosome 21

KW - Down syndrome

KW - Dscr1

KW - Heart

KW - Nervous system

KW - Nuclear factor of activated T cells

KW - Rhombomere

KW - Ts65Dn mouse

UR - http://www.scopus.com/inward/record.url?scp=0035111345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035111345&partnerID=8YFLogxK

U2 - 10.1016/S0925-4773(00)00583-9

DO - 10.1016/S0925-4773(00)00583-9

M3 - Article

C2 - 11231093

AN - SCOPUS:0035111345

VL - 101

SP - 289

EP - 292

JO - Mechanisms of Development

JF - Mechanisms of Development

SN - 0925-4773

IS - 1-2

ER -