Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor

János Balogh, Árpád Kuik, László Ürge, Ferenc Darvas, József Bakos, Rita Skoda-Földes

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Double carbonylation of iodobenzene in the presence of amines were carried out effectively in a microfluidics-based flow reactor (X-Cube™) of high throughput capability using immobilized Pd(PPh3)4 catalyst. By the proper tuning of the reaction conditions α-ketoamides could be synthesized with 70-96% selectivities depending on the choice of the nucleophile. The highest yields of double carbonylation products were obtained at relatively low temperature (80 °C) and using DBU as the base with primary amines as the reaction partners. Imine formation was observed only at higher temperatures.

Original languageEnglish
Pages (from-to)76-79
Number of pages4
JournalJournal of Molecular Catalysis A: Chemical
Volume302
Issue number1-2
DOIs
Publication statusPublished - 1 Apr 2009
Externally publishedYes

Fingerprint

Carbonylation
Microfluidics
Amines
amines
reactors
Throughput
Nucleophiles
Imines
nucleophiles
imines
Tuning
selectivity
tuning
catalysts
Temperature
Catalysts
products
iodobenzene

Keywords

  • α-Ketoamides
  • Double carbonylation
  • Flow reactor
  • Palladium

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology
  • Physical and Theoretical Chemistry

Cite this

Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor. / Balogh, János; Kuik, Árpád; Ürge, László; Darvas, Ferenc; Bakos, József; Skoda-Földes, Rita.

In: Journal of Molecular Catalysis A: Chemical, Vol. 302, No. 1-2, 01.04.2009, p. 76-79.

Research output: Contribution to journalArticle

Balogh, János ; Kuik, Árpád ; Ürge, László ; Darvas, Ferenc ; Bakos, József ; Skoda-Földes, Rita. / Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor. In: Journal of Molecular Catalysis A: Chemical. 2009 ; Vol. 302, No. 1-2. pp. 76-79.
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