Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor

János Balogh, Árpád Kuik, László Ürge, Ferenc Darvas, József Bakos, Rita Skoda-Földes

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32 Citations (Scopus)


Double carbonylation of iodobenzene in the presence of amines were carried out effectively in a microfluidics-based flow reactor (X-Cube™) of high throughput capability using immobilized Pd(PPh3)4 catalyst. By the proper tuning of the reaction conditions α-ketoamides could be synthesized with 70-96% selectivities depending on the choice of the nucleophile. The highest yields of double carbonylation products were obtained at relatively low temperature (80 °C) and using DBU as the base with primary amines as the reaction partners. Imine formation was observed only at higher temperatures.

Original languageEnglish
Pages (from-to)76-79
Number of pages4
JournalJournal of Molecular Catalysis A: Chemical
Issue number1-2
Publication statusPublished - 1 Apr 2009



  • Double carbonylation
  • Flow reactor
  • Palladium
  • α-Ketoamides

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology
  • Physical and Theoretical Chemistry

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