Donepezil and flight simulator performance: Effects on retention of complex skills

Jerome A. Yesavage, M. S. Mumenthaler, J. L. Taylor, L. Friedman, R. O'Hara, J. Sheikh, J. Tinklenberg, P. J. Whitehouse

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability to retain the capacity to perform a set of complex simulator tasks than the placebo group, p < 0.05. Donepezil appears to have beneficial effects on retention of training on complex aviation tasks in nondemented older adults.

Original languageEnglish
Pages (from-to)123-125
Number of pages3
JournalNeurology
Volume59
Issue number1
Publication statusPublished - 9 Jul 2002
Externally publishedYes

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Placebos
Aviation
Aircraft
Cholinesterase Inhibitors
donepezil
Pilots
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yesavage, J. A., Mumenthaler, M. S., Taylor, J. L., Friedman, L., O'Hara, R., Sheikh, J., ... Whitehouse, P. J. (2002). Donepezil and flight simulator performance: Effects on retention of complex skills. Neurology, 59(1), 123-125.

Donepezil and flight simulator performance : Effects on retention of complex skills. / Yesavage, Jerome A.; Mumenthaler, M. S.; Taylor, J. L.; Friedman, L.; O'Hara, R.; Sheikh, J.; Tinklenberg, J.; Whitehouse, P. J.

In: Neurology, Vol. 59, No. 1, 09.07.2002, p. 123-125.

Research output: Contribution to journalArticle

Yesavage, JA, Mumenthaler, MS, Taylor, JL, Friedman, L, O'Hara, R, Sheikh, J, Tinklenberg, J & Whitehouse, PJ 2002, 'Donepezil and flight simulator performance: Effects on retention of complex skills', Neurology, vol. 59, no. 1, pp. 123-125.
Yesavage JA, Mumenthaler MS, Taylor JL, Friedman L, O'Hara R, Sheikh J et al. Donepezil and flight simulator performance: Effects on retention of complex skills. Neurology. 2002 Jul 9;59(1):123-125.
Yesavage, Jerome A. ; Mumenthaler, M. S. ; Taylor, J. L. ; Friedman, L. ; O'Hara, R. ; Sheikh, J. ; Tinklenberg, J. ; Whitehouse, P. J. / Donepezil and flight simulator performance : Effects on retention of complex skills. In: Neurology. 2002 ; Vol. 59, No. 1. pp. 123-125.
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