Does severe hypoglycaemia influence microvascular complications in Type1 diabetes? An analysis of the Diabetes Control and Complications Trial database

E. S. Kilpatrick, A. S. Rigby, S. L. Atkin, B. M. Frier

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11 Citations (Scopus)


Aims Severe hypoglycaemia may have a role in aggravating micro- and macrovascular disease in diabetes. Data from the Diabetes Control and Complication Trial have been reanalysed to ascertain whether the frequency of severe hypoglycaemia exerted an influence on the development and progression of retinopathy or nephropathy in people with Type1 diabetes. Methods Using binary longitudinal multiple logistic regression, HbA1c at study baseline, mean HbA1c throughout the study and the number of severe hypoglycaemic episodes during the trial were compared to examine the risk of development/progression of retinopathy and nephropathy. Results Average HbA1c during the study and/or HbA1c at baseline were independently predictive of retinopathy and nephropathy both in the intensively and the conventionally treated patients (all P≤0.001). However, the number of hypoglycaemic episodes did not add to HbA1c in predicting retinopathy [odds ratio (95%CI) 0.99 (0.96-1.01), P=0.51 in intensively treated patients, 0.94 (0.89-1.00), P=0.05, conventional] or nephropathy [odds ratio (95%CI) 0.98 (0.95-1.01), P=0.48 intensive, 1.03 (0.98-1.10), P=0.17 conventional]. Conclusions The frequency of exposure to severe hypoglycaemia did not predict a different risk of developing retinopathy or nephropathy in either treatment group of the Diabetes Control and Complications Trial at any given HbA1c.

Original languageEnglish
Pages (from-to)1195-1198
Number of pages4
JournalDiabetic Medicine
Issue number9
Publication statusPublished - 1 Sep 2012



  • Glycated haemoglobin
  • Hypoglycaemia
  • Nephropathy
  • Retinopathy
  • Type1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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