Does Equol production determine soy endocrine effects?

Dana Shor, Thozhukat Sathyapalan, Stephen L. Atkin, Natalie J. Thatcher

Research output: Contribution to journalReview article

36 Citations (Scopus)


Isoflavones, a group of phytoestrogens, are selective oestrogen receptor (ER) modulators. They may positively impact endocrine-related conditions but the current evidence is sparse. Equol, a non-steroidal oestrogen, is produced by the metabolism of the isoflavone daidzein by intestinal bacteria. In Western countries, 30-50% of individuals metabolize daidzein into equol and are known as equol producers. Equol production may be the source of benefit from isoflavones in endocrine disease.

Original languageEnglish
Pages (from-to)389-398
Number of pages10
JournalEuropean Journal of Nutrition
Issue number4
Publication statusPublished - 1 Jun 2012



  • Breast cancer
  • Cardiovascular disease
  • Equol
  • Isoflavone
  • Osteoporosis
  • Phytoestrogen
  • Soy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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