DNA micelles as nanoreactors

Efficient DNA functionalization with hydrophobic organic molecules

Tuan Trinh, Pongphak Chidchob, Hassan S. Bazzi, Hanadi F. Sleiman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.

Original languageEnglish
Pages (from-to)10914-10917
Number of pages4
JournalChemical Communications
Volume52
Issue number72
DOIs
Publication statusPublished - 2016

Fingerprint

Nanoreactors
Micelles
DNA
Molecules
Nanopores
Nanotechnology
Gene Library
Oligonucleotides
Chromophores
Polymers
Drug delivery
Lipids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

DNA micelles as nanoreactors : Efficient DNA functionalization with hydrophobic organic molecules. / Trinh, Tuan; Chidchob, Pongphak; Bazzi, Hassan S.; Sleiman, Hanadi F.

In: Chemical Communications, Vol. 52, No. 72, 2016, p. 10914-10917.

Research output: Contribution to journalArticle

Trinh, Tuan ; Chidchob, Pongphak ; Bazzi, Hassan S. ; Sleiman, Hanadi F. / DNA micelles as nanoreactors : Efficient DNA functionalization with hydrophobic organic molecules. In: Chemical Communications. 2016 ; Vol. 52, No. 72. pp. 10914-10917.
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