DNA methylation in neurodegenerative disorders: A missing link between genome and environment?

S. Iraola-Guzmán, Xavier P. Estivill, R. Rabionet

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

The risk of developing neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease is influenced by genetic and environmental factors. Environmental events occurring during development or later in life can be related to disease susceptibility. One way by which the environment may exert its effect is through epigenetic modifications, which might affect the functioning of genes. These include nucleosome positioning, post-translational histone modifications, and DNA methylation. In this review we will focus in the potential role of DNA methylation in neurodegenerative disorders and in the approaches to explore such epigenetic changes. Advances in deciphering the role of epigenetic modifications in phenotype are being uncovered for a variety of diseases, including cancer, autoimmune, neurodevelopmental and cognitive disorders. Epigenetic modifications are now being also associated with cardiovascular and metabolic traits, and they are expected to be especially involved in learning and memory processes, as well as in neurodegenerative disease. The study of the role of methylation and other epigenetic modifications in disease development will provide new insights in the etiopathogenesis of neurodegenerative disorders, and should hopefully shape new avenues in the development of therapeutic strategies.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalClinical Genetics
Volume80
Issue number1
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

Fingerprint

DNA Methylation
Epigenomics
Neurodegenerative Diseases
Genome
Histone Code
Nucleosomes
Disease Susceptibility
Post Translational Protein Processing
Methylation
Parkinson Disease
Alzheimer Disease
Learning
Phenotype
Genes
Neoplasms

Keywords

  • Aging
  • DNA methylation
  • Epigenetics
  • Neurodegeneration

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

DNA methylation in neurodegenerative disorders : A missing link between genome and environment? / Iraola-Guzmán, S.; Estivill, Xavier P.; Rabionet, R.

In: Clinical Genetics, Vol. 80, No. 1, 07.2011, p. 1-14.

Research output: Contribution to journalReview article

@article{5bae899c327c4b7e9f7211e43ece3e06,
title = "DNA methylation in neurodegenerative disorders: A missing link between genome and environment?",
abstract = "The risk of developing neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease is influenced by genetic and environmental factors. Environmental events occurring during development or later in life can be related to disease susceptibility. One way by which the environment may exert its effect is through epigenetic modifications, which might affect the functioning of genes. These include nucleosome positioning, post-translational histone modifications, and DNA methylation. In this review we will focus in the potential role of DNA methylation in neurodegenerative disorders and in the approaches to explore such epigenetic changes. Advances in deciphering the role of epigenetic modifications in phenotype are being uncovered for a variety of diseases, including cancer, autoimmune, neurodevelopmental and cognitive disorders. Epigenetic modifications are now being also associated with cardiovascular and metabolic traits, and they are expected to be especially involved in learning and memory processes, as well as in neurodegenerative disease. The study of the role of methylation and other epigenetic modifications in disease development will provide new insights in the etiopathogenesis of neurodegenerative disorders, and should hopefully shape new avenues in the development of therapeutic strategies.",
keywords = "Aging, DNA methylation, Epigenetics, Neurodegeneration",
author = "S. Iraola-Guzm{\'a}n and Estivill, {Xavier P.} and R. Rabionet",
year = "2011",
month = "7",
doi = "10.1111/j.1399-0004.2011.01673.x",
language = "English",
volume = "80",
pages = "1--14",
journal = "Clinical Genetics",
issn = "0009-9163",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - DNA methylation in neurodegenerative disorders

T2 - A missing link between genome and environment?

AU - Iraola-Guzmán, S.

AU - Estivill, Xavier P.

AU - Rabionet, R.

PY - 2011/7

Y1 - 2011/7

N2 - The risk of developing neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease is influenced by genetic and environmental factors. Environmental events occurring during development or later in life can be related to disease susceptibility. One way by which the environment may exert its effect is through epigenetic modifications, which might affect the functioning of genes. These include nucleosome positioning, post-translational histone modifications, and DNA methylation. In this review we will focus in the potential role of DNA methylation in neurodegenerative disorders and in the approaches to explore such epigenetic changes. Advances in deciphering the role of epigenetic modifications in phenotype are being uncovered for a variety of diseases, including cancer, autoimmune, neurodevelopmental and cognitive disorders. Epigenetic modifications are now being also associated with cardiovascular and metabolic traits, and they are expected to be especially involved in learning and memory processes, as well as in neurodegenerative disease. The study of the role of methylation and other epigenetic modifications in disease development will provide new insights in the etiopathogenesis of neurodegenerative disorders, and should hopefully shape new avenues in the development of therapeutic strategies.

AB - The risk of developing neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease is influenced by genetic and environmental factors. Environmental events occurring during development or later in life can be related to disease susceptibility. One way by which the environment may exert its effect is through epigenetic modifications, which might affect the functioning of genes. These include nucleosome positioning, post-translational histone modifications, and DNA methylation. In this review we will focus in the potential role of DNA methylation in neurodegenerative disorders and in the approaches to explore such epigenetic changes. Advances in deciphering the role of epigenetic modifications in phenotype are being uncovered for a variety of diseases, including cancer, autoimmune, neurodevelopmental and cognitive disorders. Epigenetic modifications are now being also associated with cardiovascular and metabolic traits, and they are expected to be especially involved in learning and memory processes, as well as in neurodegenerative disease. The study of the role of methylation and other epigenetic modifications in disease development will provide new insights in the etiopathogenesis of neurodegenerative disorders, and should hopefully shape new avenues in the development of therapeutic strategies.

KW - Aging

KW - DNA methylation

KW - Epigenetics

KW - Neurodegeneration

UR - http://www.scopus.com/inward/record.url?scp=79958170373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958170373&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0004.2011.01673.x

DO - 10.1111/j.1399-0004.2011.01673.x

M3 - Review article

C2 - 21542837

AN - SCOPUS:79958170373

VL - 80

SP - 1

EP - 14

JO - Clinical Genetics

JF - Clinical Genetics

SN - 0009-9163

IS - 1

ER -