DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns

Tuan Trinh, Chenyi Liao, Violeta Toader, Maciej Barlóg, Hassan S. Bazzi, Jianing Li, Hanadi F. Sleiman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

As colloidal self-assembly increasingly approaches the complexity of natural systems, an ongoing challenge is to generate non-centrosymmetric structures. For example, patchy, Janus or living crystallization particles have significantly advanced the area of polymer assembly. It has remained difficult, however, to devise polymer particles that associate in a directional manner, with controlled valency and recognition motifs. Here, we present a method to transfer DNA patterns from a DNA cage to a polymeric nanoparticle encapsulated inside the cage in three dimensions. The resulting DNA-imprinted particles (DIPs), which are 'moulded' on the inside of the DNA cage, consist of a monodisperse crosslinked polymer core with a predetermined pattern of different DNA strands covalently 'printed' on their exterior, and further assemble with programmability and directionality. The number, orientation and sequence of DNA strands grafted onto the polymeric core can be controlled during the process, and the strands are addressable independently of each other.

Original languageEnglish
Pages (from-to)184-192
Number of pages9
JournalNature Chemistry
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Fingerprint

Polymers
DNA
Nanoparticles
Crystallization
Self assembly

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns. / Trinh, Tuan; Liao, Chenyi; Toader, Violeta; Barlóg, Maciej; Bazzi, Hassan S.; Li, Jianing; Sleiman, Hanadi F.

In: Nature Chemistry, Vol. 10, No. 2, 01.02.2018, p. 184-192.

Research output: Contribution to journalArticle

Trinh, T, Liao, C, Toader, V, Barlóg, M, Bazzi, HS, Li, J & Sleiman, HF 2018, 'DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns', Nature Chemistry, vol. 10, no. 2, pp. 184-192. https://doi.org/10.1038/NCHEM.2893
Trinh, Tuan ; Liao, Chenyi ; Toader, Violeta ; Barlóg, Maciej ; Bazzi, Hassan S. ; Li, Jianing ; Sleiman, Hanadi F. / DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns. In: Nature Chemistry. 2018 ; Vol. 10, No. 2. pp. 184-192.
@article{c467044abb9d4454a036574ea6073f51,
title = "DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns",
abstract = "As colloidal self-assembly increasingly approaches the complexity of natural systems, an ongoing challenge is to generate non-centrosymmetric structures. For example, patchy, Janus or living crystallization particles have significantly advanced the area of polymer assembly. It has remained difficult, however, to devise polymer particles that associate in a directional manner, with controlled valency and recognition motifs. Here, we present a method to transfer DNA patterns from a DNA cage to a polymeric nanoparticle encapsulated inside the cage in three dimensions. The resulting DNA-imprinted particles (DIPs), which are 'moulded' on the inside of the DNA cage, consist of a monodisperse crosslinked polymer core with a predetermined pattern of different DNA strands covalently 'printed' on their exterior, and further assemble with programmability and directionality. The number, orientation and sequence of DNA strands grafted onto the polymeric core can be controlled during the process, and the strands are addressable independently of each other.",
author = "Tuan Trinh and Chenyi Liao and Violeta Toader and Maciej Barl{\'o}g and Bazzi, {Hassan S.} and Jianing Li and Sleiman, {Hanadi F.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1038/NCHEM.2893",
language = "English",
volume = "10",
pages = "184--192",
journal = "Nature Chemistry",
issn = "1755-4330",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns

AU - Trinh, Tuan

AU - Liao, Chenyi

AU - Toader, Violeta

AU - Barlóg, Maciej

AU - Bazzi, Hassan S.

AU - Li, Jianing

AU - Sleiman, Hanadi F.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - As colloidal self-assembly increasingly approaches the complexity of natural systems, an ongoing challenge is to generate non-centrosymmetric structures. For example, patchy, Janus or living crystallization particles have significantly advanced the area of polymer assembly. It has remained difficult, however, to devise polymer particles that associate in a directional manner, with controlled valency and recognition motifs. Here, we present a method to transfer DNA patterns from a DNA cage to a polymeric nanoparticle encapsulated inside the cage in three dimensions. The resulting DNA-imprinted particles (DIPs), which are 'moulded' on the inside of the DNA cage, consist of a monodisperse crosslinked polymer core with a predetermined pattern of different DNA strands covalently 'printed' on their exterior, and further assemble with programmability and directionality. The number, orientation and sequence of DNA strands grafted onto the polymeric core can be controlled during the process, and the strands are addressable independently of each other.

AB - As colloidal self-assembly increasingly approaches the complexity of natural systems, an ongoing challenge is to generate non-centrosymmetric structures. For example, patchy, Janus or living crystallization particles have significantly advanced the area of polymer assembly. It has remained difficult, however, to devise polymer particles that associate in a directional manner, with controlled valency and recognition motifs. Here, we present a method to transfer DNA patterns from a DNA cage to a polymeric nanoparticle encapsulated inside the cage in three dimensions. The resulting DNA-imprinted particles (DIPs), which are 'moulded' on the inside of the DNA cage, consist of a monodisperse crosslinked polymer core with a predetermined pattern of different DNA strands covalently 'printed' on their exterior, and further assemble with programmability and directionality. The number, orientation and sequence of DNA strands grafted onto the polymeric core can be controlled during the process, and the strands are addressable independently of each other.

UR - http://www.scopus.com/inward/record.url?scp=85040974795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040974795&partnerID=8YFLogxK

U2 - 10.1038/NCHEM.2893

DO - 10.1038/NCHEM.2893

M3 - Article

VL - 10

SP - 184

EP - 192

JO - Nature Chemistry

JF - Nature Chemistry

SN - 1755-4330

IS - 2

ER -