Disruption of amyloid-derived peptide assemblies through the controlled induction of a β-sheet to α-helix transformation: Application of the switch concept

Richard Mimna, Marie Stéphanie Camus, Adrian Schmid, Gabriele Tuchscherer, Hilal A. Lashuel, Manfred Mutter

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

(Figure Presented) Most problems are soluble: Reversal of amyloid formation through a controlled induced transformation from β-sheet to soluble α-helix structures through the use of a switch element S (see scheme, σ is a helix-inducing template) could have an important consequences understanding the mechanisms of amyloid formation and clearance.

Original languageEnglish
Pages (from-to)2681-2684
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number15
DOIs
Publication statusPublished - 29 Jun 2007

    Fingerprint

Keywords

  • Amyloid fibrils
  • Conformational transitions
  • Fibril disruption
  • Neurodegenerative diseases
  • Switch peptides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this