Disentangling the relationship between tumor genetic programs and immune responsiveness

Davide Bedognetti, Wouter R. Hendrickx, Michele Ceccarelli, Lance D. Miller, Barbara Seliger

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Correlative studies in humans have demonstrated that an active immune microenvironment characterized by the presence of a T-helper 1 immune response typifies a tumor phenotype associated with better outcome and increased responsiveness to immune manipulation. This phenotype also signifies the counter activation of immune-regulatory mechanisms. Variables modulating the development of an effective anti-tumor immune response are increasingly scrutinized as potential therapeutic targets. Genetic alterations of cancer cells that functionally influence intratumoral immune response include mutational load, specific mutations of genes involved in oncogenic pathways and copy number aberrations involving chemokine and cytokine genes. Inhibiting oncogenic pathways that prevent the development of the immune-favorable cancer phenotype may complement modern immunotherapeutic approaches.

Original languageEnglish
Pages (from-to)150-158
Number of pages9
JournalCurrent Opinion in Immunology
Volume39
DOIs
Publication statusPublished - 1 Apr 2016

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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